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MAP3K7 — XIAP

Pathways - manually collected, often from reviews:

• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → TAK1/SMAD6 complex (MAP3K7-SMAD6) (modification, activates)
  Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, activates)
  Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TGF-beta receptor signaling: TAK1/XIAP complex (MAP3K7-XIAP) → XIAP (XIAP) (modification, collaborate) Edlund et al., Mol Biol Cell 2003, Kaur et al., J Biol Chem 2005, Hong et al., Nat Immunol 2007, Yamaguchi et al., Science 1995
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: TAK1/XIAP complex (MAP3K7-XIAP) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, collaborate)
  Edlund et al., Mol Biol Cell 2003, Kaur et al., J Biol Chem 2005, Hong et al., Nat Immunol 2007, Yamaguchi et al., Science 1995
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TGF-beta receptor signaling: XIAP (XIAP) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, collaborate)
  Edlund et al., Mol Biol Cell 2003, Kaur et al., J Biol Chem 2005, Hong et al., Nat Immunol 2007, Yamaguchi et al., Science 1995
  Evidence: mutant phenotype, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: XIAP — MAP3K7 (physical association, affinity chromatography technology) Resch et al., J Cell Sci 2009*
• IRef Biogrid Interaction: XIAP — MAP3K7 (physical association, affinity chromatography technology) Sanna et al., Mol Cell Biol 2002*
• IRef Biogrid Interaction: XIAP — MAP3K7 (physical association, affinity chromatography technology) Sanna et al., J Biol Chem 2002*
• IRef Hprd Interaction: XIAP — MAP3K7 (in vitro) Sanna et al., J Biol Chem 2002*
• IRef Hprd Interaction: XIAP — MAP3K7 (in vivo) Sanna et al., J Biol Chem 2002*
• IRef Innatedb Interaction: XIAP — MAP3K7 (unknown, -) Sanna et al., J Biol Chem 2002*
• IRef Innatedb Interaction: XIAP — MAP3K7 (unknown, -) Sanna et al., Mol Cell Biol 2002*
• IRef Ophid Interaction: XIAP — MAP3K7 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Sanna et al., Mol Cell Biol 2002 : Importantly, expression of catalytically inactive TAK1 did not affect XIAP inhibition of caspase activity
Sanna et al., J Biol Chem 2002 : The expression of a catalytically inactive mutant of TAK1 blocked XIAP/ILPIP synergistic activation of JNK1 thereby implicating TAK1 in this signaling pathway
Lu et al., Mol Cell 2007 : Structure based mutagenesis and knockdown of TAB1 show unambiguously that the BIR1/TAB1 interaction is crucial for XIAP induced TAK1 and NF-kappaB activation
Jin et al., Cancer Res 2009 (MAP Kinase Signaling System) : XIAP mediates activation of the upstream IKK kinase, TAK1 , and couples activated TAK1 to the IKK complex