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CD28 — NFKB1

Text-mined interactions from Literome

Olsson et al., J Biol Chem 1999 : CTLA-4 ligation suppresses CD28 induced NF-kappaB and AP-1 activity in mouse T cell blasts
Coudronniere et al., Proc Natl Acad Sci U S A 2000 : NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta ... Fourth, CD3/CD28 induced CD28RE/AP-1 activation and NF-kappaB nuclear translocation were blocked by a selective PKCtheta inhibitor
Lin et al., Mol Cell Biol 2000 : Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta ... Conversely, expression of a kinase-deficient mutant or antisense PKC-theta selectively inhibits CD3-CD28 costimulation , but not tumor necrosis factor alpha induced activation of NF-kappaB in Jurkat T cells
Dienz et al., J Biol Chem 2000 : CD3/CD28 induced activation of NF-kappaB was inhibited by dominant negative forms of Vav or PKCtheta, revealing their essential role in this activation pathway
Bounou et al., J Biol Chem 2001 : The increase of NF-kappa B activity was abolished when infection with B7-2 bearing HIV-1 particles was performed in the presence of the fusion protein CTLA-4 Ig suggesting that the interaction between virally embedded B7-2 and CD28 on the target cell is responsible for the observed NF-kappa B induction
Herndon et al., J Immunol 2001 : ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28 ... Reexpression of ZAP-70 restored PKCtheta and NF-kappaB activation in response to TCR and CD28 coengagement ... These data illustrate the importance of the ZAP-70/SLP-76 signaling pathway in CD3/CD28 stimulated activation of PKC theta and NF-kappaB , and suggest that Vav-1 association with SLP-76 may be important in this pathway
Simpson et al., Expert Opin Investig Drugs 2001 (Graft vs Host Disease) : NF-kappa B is also required for CD28 ligation signalling, important in late co-stimulation
Gaide et al., Nat Immunol 2002 : Together, our data show that CARMA1 is a critical lipid raft associated regulator of TCR induced NF-kappa B activation and CD28 costimulation dependent Jnk activation
Dienz et al., J Immunol 2003 : In contrast, replenishment of SLP-76 or PLCgamma1 expression restored CD3/CD28 induced IkappaB kinase (IKK) activity as well as NF-kappaB DNA binding and transactivation
Wang et al., Mol Cell Biol 2004 : CD3/CD28 costimulation induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1 ... This membrane association is essential for the function of CARMA1, since a mutant of CARMA1, CARMA1 ( L808P ), that is defective in the membrane association can not rescue CD3/CD28 costimulation induced NF-kappaB activation in JPM50.6 CARMA1-deficient T cells ... Consistently, expression of a mutant CARMA1, CARMA1 ( DeltaCD ), that can not associate with Bcl10 failed to restore CD3/CD28 costimulation induced NF-kappaB activation in JPM50.6 cells, whereas expression of Bcl10-CARMA ( DeltaCD ) fusion protein effectively restored this NF-kappaB activation ... Together, these results indicate that CARMA1 mediates CD3/CD28 costimulation induced NF-kappaB activation by recruiting downstream signaling components into the immunological synapse
Lynch et al., Mol Interv 2004 : The molecular mechanisms by which NF-kappaB is activated by TCR-CD28 have only recently become known
Kim et al., J Immunol 2004 (MAP Kinase Signaling System...) : In contrast, p75 is nonredundantly coupled to sustained AKT activity and NF-kappaB activation in response to TCR/CD28 mediated stimulation
Li et al., J Biol Chem 2005 : We found that TCR/CD28 costimulation activates the canonical but not the non-canonical NF-kappaB pathway and that the serine/threonine kinase protein kinase C ( PKC ) is essential for TCR/CD28 mediated canonical NF-kappaB activation in T cells
Nishiyama et al., Int Immunopharmacol 2005 : Cyclosporin A inhibits the early phase of NF-kappaB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells
Broderick et al., Clin Immunol 2006 (Carcinoma, Non-Small-Cell Lung...) : Little translocation of NF-kappaB or NFAT occurred in tumor associated T cells in response to CD3+CD28 cross linking under conditions which led to maximal translocation in normal donor peripheral blood T cells
Narayan et al., Mol Cell Biol 2006 : We previously demonstrated a role for the serine/threonine kinase Akt in CD28 mediated NF-kappaB induction
Watanabe et al., J Immunol 2006 : In this study, we show that Gads, but not Grb2, is essential for CD28 mediated NF-kappaB activation , and its binding to CD28 requires the whole CD28 cytoplasmic domain in addition to the YMNM motif
Bahlis et al., Blood 2007 (Multiple Myeloma) : We have found that direct activation of myeloma cell CD28 by anti-CD28 mAb alone induces activation of PI3K and NFkappaB , suppresses MM cell proliferation, and protects against serum starvation and dexamethasone ( dex ) -induced cell death
Gruber et al., Mol Immunol 2008 : Importantly, however, both atypical PKCzeta and PKCiota were functionally required in TCR/CD28 mediated activation of NF-kappaB downstream of PKCtheta in Jurkat T cells albeit, activation responses of PKCzeta-deficient CD3+ T cells were comparable with wildtype controls
Ronchetti et al., J Immunol 2007 : As a consequence, up-regulation of Bcl-x ( L ), one of the major target proteins of CD28 dependent NF-kappaB activation, was defective in costimulated GITR ( -/- ) CD8 ( + ) T cells
Zhou et al., Allergy 2008 (Asthma...) : Significantly, AdIkappaBalphaM inhibited CD3/CD28 mediated NF-kappaB activation in CD45RO ( + ) T cells, leading to evident apoptosis, reduction of eotaxin, RANTES, Th1 [ interferon (IFN)-gamma and interleukin (IL)-2 ], and Th2 ( IL-4, IL-5, and IL-13 despite a slight decrease in IL-10 ) cytokines and secondary proliferative response
Koh et al., Biochem Biophys Res Commun 2008 : From these results, we concluded that the regulation of CD7 gene expression through NF-kappaB activation induced by TCR/CD28 might have significant implications for T-cell homeostasis
Takeda et al., Int Immunol 2008 : CD28 stimulation triggers NF-kappaB activation through the CARMA1-PKCtheta-Grb2/Gads axis ... However, the signal transducing cascades linking the CD28 molecule and activation of NF-kappaB remain unclear ... To examine the role of these molecules in NF-kappaB activation through CD28 mediated stimulation, Bcl10 was over expressed in Jurkat cells and their NF-kappaB activation by CD28- or TCR-cross linking was evaluated ... We found that CD28 stimulation alone can induce NF-kappaB activation in Bcl10-over expressing Jurkat cells, whereas TCR stimulation alone has only little effect ... In addition, we found that Bcl10 induced NF-kappaB activation through CD28 mediated stimulation could be blocked by the dominant negative form of PKC or CARMA1 ... Furthermore, genetic studies revealed that Grb2/Gads binding, but not phosphatidylinositol 3-kinase binding, is important in CD28 mediated NF-kappaB activation
Lai et al., Mol Cell Biol 1995 : We also showed that c-Rel, but not NFKB1 ( p50 ), can bind to the CD28RE and activate CD28RE-driven transcription in cotransfection assays
Los et al., EMBO J 1995 : IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase ... In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen intermediates ( ROIs ) which are required for CD28 mediated activation of the NF-kappa B/CD28-responsive complex and IL-2 expression
Los et al., Biochem J 1994 : Whereas anti-CD28 together with PMA increased the DNA binding and trans-activation activity of NF-kappa B , PMA induced activation of AP-1 was significantly suppressed
Edmead et al., J Immunol 1996 : Using selective inhibitors, we investigated the signaling pathways involved in the CD28 mediated induction of AP-1 and NF-kappaB
Harhaj et al., Mol Cell Biol 1996 : In this report, we show that CD28 costimulation leads to biphasic induction of NF-kappaB/Rel heterodimers, including early-phase induction of p50/RelA and c-Rel/RelA and late-phase induction of p50/c-Rel ... Interestingly, activation of these NF-kappaB/Rel complexes by the CD28 signal is associated with the rapid degradation of both IkappaBalpha and IkappaBbeta, two major cytoplasmic inhibitors of NF-kappaB/Rel
Gringhuis et al., Blood 1997 (Leukemia-Lymphoma, Adult T-Cell) : T-cell receptor (TCR)/CD3 engagement results in the activation of nuclear factor of activated T cells ( NFAT ), activator protein-1 (AP-1), and nuclear factor kappaB (NFkappaB) , whereas the CD28 responsive complex (CD28RC) is activated in response to the CD28 signal
Kalli et al., Mol Cell Biol 1998 : Together, these results suggest a mechanism by which signals from the T-cell antigen receptor and either CD28 or IL-1 synergistically regulate IL-2 gene transcription by modulating NF-kappaB nuclear translocation
Lahdenpohja et al., J Leukoc Biol 1998 : We have analyzed the effect of complete T cell activation ( anti-CD3 plus anti-CD28 ) on the activation of NF-kappaB in CD45RA+ ( naive ) and CD45RO+ ( memory/effector ) T cells
Harhaj et al., J Biol Chem 1998 : Enhanced activation of NF-kappaB by CD28 is mediated by rapid phosphorylation and proteasome mediated degradation of the NF-kappaB inhibitory proteins IkappaB alpha and IkappaB beta, which allows for accelerated nuclear expression of the liberated NF-kappaB