Gene interactions and pathways from curated databases and text-mining

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KIT — NFKB1

Text-mined interactions from Literome

Lin et al., J Med Chem 2009 (Lung Neoplasms) : We further confirmed that PBT-1 suppressed Akt activation accelerated RelA degradation via IkappaB kinase-alpha and down-regulated NF-kappaB target gene expression
Liu et al., Cancer Cell 2010 (Leukemia, Myeloid) : Our results provide evidence that the mechanisms of Sp1/NFkappaB/HDAC/miR-29b dependent KIT overexpression contribute to leukemia growth and can be successfully targeted by pharmacological disruption of the Sp1/NFkappaB/HDAC complex or synthetic miR-29b treatment in KIT-driven AML