Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
CXCL8
→
IL13
(increases)
Kawaguchi et al., J Allergy Clin Immunol 2001* Evidence: Stimulation of the cells with each of the 3 cytokines IL-17, IL-4, and IL-13 induces the expression of both IL-6 and IL-8 (Fig 4), and among all 4 cytokines IL-17 is the most potent inducer. However, IL-17 alone did not induce ICAM-1 expression, which is in contrast to the finding of a significant induction of ICAM-1 expression by 3 other cytokines (Fig 4).
OpenBEL Selventa BEL large corpus:
CXCL8
→
IL13
(increases)
Evidence: TGFB1 and IL-13 induced the increase in levels of IL-8.
OpenBEL Selventa BEL large corpus:
CXCL8
→
IL13
(increases)
Evidence: IL-13 increased expression of the proinflammatory cytokines MCP-1 and IL-8 in TNF?? challenged VSMC [105].