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CDC6 — E2F1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: CDC6 — E2F1 (physical association, proximity ligation assay) Liu et al., Mol Cell Proteomics 2013

Text-mined interactions from Literome

Yan et al., Proc Natl Acad Sci U S A 1998 : Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
Hateboer et al., Mol Cell Biol 1998 : Furthermore, E2F is sufficient to induce expression of the endogenous CDC6 gene even in the absence of de novo protein synthesis
Ohtani et al., Oncogene 1998 : Expression of endogenous Cdc6 was induced by exogenous expression of E2F ... Therefore, we concluded that the growth regulated expression of mammalian Cdc6 was mediated by E2F ... Moreover, we demonstrated that exogenous overexpression of either HsCdc6 or HsOrc1 failed to induce DNA synthesis unlike overexpression of E2F1, even though E2F1 induced both Cdc6 and Orc1, suggesting that E2F may regulate the expression of another gene ( s ), besides Cdc6 and Orc1, required for induction of cellular DNA synthesis in mammalian cells