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IL6 — PRKCA
Text-mined interactions from Literome
Boudreau et al., J Biol Chem 2002
:
Protein phosphatase 2A and
protein kinase Calpha are physically associated and are
involved in Pseudomonas aeruginosa induced
interleukin 6 production by mast cells
Bordin et al., Biochemistry 2003
:
Arachidonic acid induced
IL-6 expression is
mediated by
PKC alpha activation in osteoblastic cells
Kwon et al., J Dermatol Sci 2007
(MAP Kinase Signaling System) :
Over-expression of
PKCalpha markedly
induced the
IL-6 expression and p42/44 ERK activation
Wyatt et al., Am J Physiol Lung Cell Mol Physiol 2007
:
The
PKCalpha inhibitor, Gö-6976, did not
inhibit FLDE stimulated IL-8 and
IL-6 release
Chiu et al., Mol Immunol 2008
:
Thrombin induced
IL-6 production in human synovial fibroblasts is
mediated by PAR1, phospholipase C,
protein kinase C alpha , c-Src, NF-kappa B and p300 pathway
Fehrenbach et al., J Immunol 2009
:
Specifically, although we found that the conventional PKC inhibitor, Gö6976, likely has some PKC independent targets in MCs, it led us to further studies that established SF plus Ag-induced
IL-6 secretion was severely
impaired in PKC-beta ( -/- ) MCs, but not
PKC-alpha ( -/- ) MCs