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CD4 — SELL
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Marschner et al., Proc Natl Acad Sci U S A 1999
:
Here, we show that ligation of
CD4 , without ligation of the T cell receptor for antigen,
causes down-regulation of
L-selectin on T helper cells ... Because CD4 is a coreceptor for HIV-1, the down-regulation of
L-selectin induced by
CD4 ligation could play a role in the pathogenesis of AIDS
Cloyd et al., Curr Mol Med 2001
(HIV Infections...) :
HIV binding to, and signaling through,
CD4 and chemokine receptor molecules on resting CD4 lymphocytes and other cell types [ which extensively occurs as the rare, productively infected cells ( ie : infected cells producing virus ) migrate among other cells through the lymphoid tissues back into the blood ]
induces upregulation of
L-selectin and Fas
Savage et al., Eur J Immunol 2002
:
Here, we demonstrate that surface expression of
CD62L enhances
CD4 ( + ) T cell activation in vitro
Weigmann et al., J Immunol 2004
(Colitis...) :
In contrast, transfer of CD4 ( + ) CD62L ( - ) T cells from c-Maf transgenic, but not wild-type mice induced colitis and augmented colitis
induced by
CD4 ( + )
CD62L ( + ) T cells from wild-type mice in an IL-4 independent pathway, as determined by macroscopic, histologic, and endoscopic criteria
Kim et al., PloS one 2013
:
Curcumin not merely blocks, but
regulates CD2/CD3/CD28 initiated
CD4 ( + ) T cell activation by augmenting CD69, CCR7,
L-selectin and TGF-ß1 expression followed by regulatory T cell generation
Yamazaki et al., Hum Immunol 2013
(Angiolymphoid Hyperplasia with Eosinophilia) :
Increased CD45RO ( + )
CD62L ( + )
CD4 ( + ) T-cell subpopulation responsible for Th2 response in Kimura 's disease