◀ Back to IRS1

ANGPT2 — IRS1

Text-mined interactions from Literome

Izawa et al., Exp Cell Res 2005 (Hypertension...) : Ang II induced extracellular signal regulated kinase ( ERK ) 1/2 and c-Jun N-terminal kinase (JNK) activation and IRS-1 phosphorylation at Ser307 and Ser616
Arellano-Plancarte et al., Biochem Pharmacol 2010 (Insulin Resistance) : Studies with specific inhibitors of PI3K ( wortmannin ) and mTOR ( rapamycin ) revealed that Ang II stimulates IRS-1 phosphorylation of Ser ( 636 ) /Ser ( 639 ) via the PI3K/mTOR/S6K-1 pathway
Hitomi et al., Am J Physiol Cell Physiol 2011 (Hypertrophy...) : We conclude that phosphorylation of Ser307, Ser302, and Ser632 of IRS-1 is not involved in ANG II-mediated IRS-1 degradation, and that JNK alone does not mediate ANG II-stimulated IRS-1 degradation, but rather is responsible for the hypertrophic effects of insulin on smooth muscle