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EZH2 — STAT3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chen et al., Cell cycle (Georgetown, Tex.) 2013
:
Because As ( 3+ ) is capable of inducing miRNA-21 (miR-21), a STAT3 regulated miRNA that represses protein translation of PTEN or Spry2, we also tested the
role of
STAT3 and miR-21 in As ( 3+ ) -induced
EZH2 phosphorylation
Lin et al., J Pathol 2013
(Colorectal Neoplasms...) :
EZH2 expression may be directly
regulated by
STAT3 , and STAT3 may play an important role in EZH2 mediated VDR down-regulation in CRC
Kim et al., Cancer Cell 2013
(Cell Transformation, Neoplastic...) :
The
EZH2-STAT3 interaction preferentially occurs in GSCs relative to non-stem bulk tumor cells, and it
requires a specific phosphorylation of
EZH2 ... Inhibition of
EZH2 reverses the silencing of Polycomb target genes and
diminishes STAT3 activity, suggesting therapeutic strategies
Fouse et al., Cancer Cell 2013
(Glioblastoma) :
In this issue of Cancer Cell, Kim and colleagues discover that
EZH2 enhances
STAT3 activation by trimethylating lysine180 in STAT3 and does so preferentially in glioma stem-like cells