◀ Back to TP53
EGFR — TP53
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
TP53
→
EGFR
(decreases)
Evidence: In addition, immunohistochemical analysis showed that the expression of wild-type p53 was significantly increased in the antisense-EGFR cDNA transfected clones,
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WikiPathways Gastric Cancer Network 2:
TP53
→
EGFR
(activation)
Text-mined interactions from Literome
Sun et al., Mol Carcinog 1999
(Neoplasm Metastasis) :
p53 transcriptionally
activates expression of the genes encoding
epidermal growth factor receptor , matrix metalloproteinase (MMP)-2, cathepsin D, and thrombospondin-1 but represses expression of the genes encoding basic fibroblast growth factor and multidrug resistance-1
Halatsch et al., Anticancer Res 2001
(Glioblastoma) :
This study sought to investigate whether overexpression of deletion-mutant ( delta )
EGFR affects genotoxic stress provoked mRNA inductions of
p53 and murine double minute 2 (MDM2), two other genes strongly involved in the pathogenesis of GBM
Lin et al., Cancer Res 2002
(Breast Neoplasms) :
Expression of wt
p53 did not
cause a reduction in the phosphorylation of three unrelated protein kinases in other signal transduction pathways, AKT, extracellular signal regulated kinase ( ERK ) 1, and ERK2 or a reduction of phosphorylation of
epidermal growth factor receptor
Purow et al., Carcinogenesis 2008
(Brain Neoplasms...) :
Experiments with p53 positive and -null cell lines confirmed that
p53 partially
mediates the effects of Notch-1 on
EGFR expression
Bheda et al., Oncogene 2008
:
Loss of
p53 induces
epidermal growth factor receptor promoter activity in normal human keratinocytes ... Exogenous wild-type
p53 inhibits the
EGFR promoter at low levels, and activates it at higher concentrations ... Wild-type
p53 suppressed Sp1- and YY1 mediated induction of the
EGFR promoter
Nie et al., Mol Cancer Ther 2008
(Colonic Neoplasms...) :
AAV-HGFK1+Ad-p53 also inhibited tumor cell growth in vitro by
inhibiting epidermal growth factor receptor phosphorylation
Rieber et al., Int J Cancer 2009
(Breast Neoplasms...) :
Since the p53 tumor suppressor pathway is inactivated in most human cancers due to gene mutations or defective wt p53 signaling, we now investigated in human wt p53 breast carcinoma MCF-7 cells, whether single treatment with the p53 transactivation pharmacological inhibitor pifithrin-alpha, transient p53 siRNA interference or stable insertion of a dominant negative ( DN ) R175H
p53 mutant increase : ( i )
EGFR/erbB1 activation , ( ii ) MMP-9 expression and ( iii ) loss of surface E-cadherin
Klanrit et al., Oncogene 2009
(Head and Neck Neoplasms) :
p53 activates
EGFR expression, whereas TAp63 represses EGFR transcription
Muller et al., Cell 2009
(Neoplasm Metastasis) :
These activities of
p53 reflect enhanced integrin and epidermal growth factor receptor (EGFR) trafficking, which depends on Rab coupling protein (RCP) and
results in constitutive activation of
EGFR/integrin signaling
Sauer et al., Oncogene 2010
(MAP Kinase Signaling System...) :
Finally,
p53 may further
regulate this feedback loop by altering the level of
EGFR expression
Watt et al., J Neurooncol 2010
(Glioma) :
This was in agreement with the fact that
p53 activation did not induce Bax upregulation nor did
EGFR inhibition
promote Bad dephosphorylation
Deb et al., Oncogene 1994
:
Wild-type human
p53 activates the human
epidermal growth factor receptor promoter ... We propose that
p53 successfully nucleates the transcription complex, possibly via direct interaction with TFIID, and
activates the
EGFR promoter
Ludes-Meyers et al., Mol Cell Biol 1996
:
Transcriptional
activation of the human
epidermal growth factor receptor promoter by human
p53 ... The human
epidermal growth factor receptor (EGFR) promoter is
activated by both wild-type and tumor derived mutant
p53 ... We further show that the
EGFR promoter is also
activated by tumor derived
p53 mutants p53-143A, p53-175H, p53-248W, p53-273H, and p53-281G ... The minimal
EGFR promoter from positions -- 104 to -- 20 which does not contain the wild-type p53 binding site is
transactivated by the
p53 mutants but not by the wild-type protein, showing a difference in the mechanism of transactivation by wild-type and mutant p53 ...
Transactivation of the
EGFR promoter by
p53 may represent a novel mechanism of cell growth regulation
Sheikh et al., Oncogene 1997
(Breast Neoplasms) :
We investigated the
p53 regulation of
EGF-R core promoter activity in human cell lines with varying endogenour p53 status ... Wild-type and mutant
p53Ala143 enhanced the
EGF-R core promotor activity in cells that were either p53-deficient or contained wild-type or mutant endogenous p53