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BDKRB2 — TP53

Pathways - manually collected, often from reviews:

• NCI Pathway Database Direct p53 effectors: p53 (tetramer) complex (TP53) → BK2 (BDKRB2) (transcription, activates) Saifudeen et al., J Biol Chem 2000*
  Evidence: mutant phenotype, reporter gene, physical interaction, other species

Text-mined interactions from Literome

Saifudeen et al., J Biol Chem 2000 : We report here that the rat BK2 receptor is transcriptionally regulated by the tumor suppressor protein p53
El-Dahr et al., American journal of physiology. Renal physiology 2008 (Congenital Abnormalities) : Thus, although BdkrB2 is a target for p53 mediated transcriptional activation, BdkrB2 is required to restrict p53 proapoptotic activity ... Thus, although BdkrB2 is a target for p53 mediated transcriptional activation, BdkrB2 is required to restrict p53 proapoptotic activity
El-Dahr et al., Biol Chem 2013 : Thus, while BdkrB2 is a target for p53 mediated transcriptional activation, BdkrB2 inactivation results in the upregulation of checkpoint kinase 1 (Chk1) levels, thus potentiating phosphorylation of p53 on Ser23 by Chk1, an essential step in the pathway leading to renal dysgenesis in salt stressed BdkrB2 ( -/- ) mutant mice