◀ Back to INSR

INSR — RAPGEF1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CRK-RAPGEF1 → INSR (increases, INSR Translocation, CRK/RAPGEF1 Activity)
  Evidence: Translocation of phosphorylated Cbl recruits the adapter protein CrkII to the lipid raft via interaction of the SH2 domain of CrkII with phospho-Cbl51. CrkII also forms a constitutive complex with the guanyl nucleotide-exchange protein C3G. Once translocated into lipid rafts, C3G comes into proximity with the G protein TC10, and catalyses the exchange of GTP for GDP, resulting in the activation of the protein51.
• OpenBEL Selventa BEL large corpus: RAPGEF1 → INSR (increases, INSR Activity, RAPGEF1 Activity)
  Evidence: Translocation of phosphorylated Cbl recruits the adapter protein CrkII to the lipid raft via interaction of the SH2 domain of CrkII with phospho-Cbl51. CrkII also forms a constitutive complex with the guanyl nucleotide-exchange protein C3G. Once translocated into lipid rafts, C3G comes into proximity with the G protein TC10, and catalyses the exchange of GTP for GDP, resulting in the activation of the protein51.