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PCNA — UCN
Text-mined interactions from Literome
Sugiyama et al., Cancer Res 1999
(Lung Neoplasms) :
UCN-01 induced down-regulation of
cyclin A level and CDK2 activity accompanied with its dephosphorylation in A549/UCN cells, but not in A549 cells
Bunch et al., Cell Growth Differ 1997
:
In searching for an explanation for this accelerate DNA synthesis, we discovered that
UCN-01 caused translocation of
proliferating cell nuclear antigen ( PCNA ) to the detergent-insoluble, DNA bound fraction
Shao et al., Cancer Res 1997
:
In this study, we found that nanomolar concentrations of camptothecin ( CPT ), a topoisomerase I inhibitor, arrest or delay cell cycle progression during the S and G2 phases in p53 mutant human colon carcinoma HT29 cells and that
UCN-01 abrogates the S-phase arrest or delay induced by CPT. Under these conditions, CPT
increased cyclin A levels and cyclin A/cyclin dependent kinase 2 activity ...
UCN-01 prevented the increase of
cyclin A/cyclin dependent kinase 2 activity induced by CPT and enhanced Cdc2 kinase activity