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HRAS — IGF1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1)
→
HRAS/GTP complex (HRAS)
(modification, activates)
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc complex (IGF1R-IGF1-GRB2-SHC1-SOS1)
→
HRAS/GDP complex (HRAS)
(modification, activates)
-
NCI Pathway Database IGF1 pathway:
IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos complex (IGF1R-IGF1-IRS1-GRB2-SOS1)
→
HRAS/GDP complex (HRAS)
(modification, activates)
Text-mined interactions from Literome
Burgering et al., Mol Cell Biol 1989
(Cell Transformation, Neoplastic) :
This implies that overexpression of normal
H-ras in the
presence of
insulin/IGF-1 is functionally similar to the expression of mutant H-ras, since mutant H-ras can circumvent this block by itself
Valverde et al., Exp Cell Res 1995
:
Moreover, DBcAMP inhibited in parallel H-ras mRNA expression,
p21 ras , and proliferating cellular nuclear antigen protein content
induced by
IGF-I at 24 and 48 h of culture, respectively, suggesting the involvement of p21 ras in the progression of fetal brown adipocytes through the S phase of the cell cycle and DNA synthesis
Luttrell et al., J Biol Chem 1995
:
The
IGF1 , LPA, and EGF receptor mediated signals are all sensitive to inhibitors of tyrosine protein kinases,
require p21ras activation, and are independent of protein kinase C
Dawson et al., Cancer Res 1995
:
Expression of mutant
p21ras induces
insulin-like growth factor 1 secretion in thyroid epithelial cells ... Expression of mutant
p21ras in these cells, induced by Zn2+,
resulted in an approximate 30-fold increase in the
IGF-1 production rate, reaching a level exceeding that of human embryo fibroblasts
Robinson et al., Endocrinology 1994
:
The aims of this study were to determine if insulin and
IGF-I activate
p21ras in fetal chick forebrain neurons and if activation of p21ras mediates the neurotrophic actions of these peptides ... Insulin and IGF-I increased the ratio of GTP/GTP + GDP by 31 +/- 9.0 % and 36 +/- 8.0 %, respectively,
p21Ras activation by insulin and
IGF-I was maximal within 5 min ... Pretreatment of neurons with lovastatin ( 2 micrograms/ml ), an inhibitor of ras isoprenylation, completely blocked the
activation of
p21ras by insulin and
IGF-I ... We conclude that insulin and
IGF-I activate
p21ras in fetal chick forebrain neurons by increasing the amount of GTP bound to p21ras ... The activation of neuronal
p21ras is
necessary for insulin and
IGF-I to promote survival and differentiation in these neurons
Jhun et al., J Biol Chem 1994
:
Insulin and
insulin-like growth factor-I signal transduction
requires p21ras ... We have investigated the
role of cellular
p21ras protein in insulin and
insulin-like growth factor-I (IGF-I) signaling pathways
Lorenzo et al., J Cell Biol 1993
:
IGF-I increased mRNA expression of the early-response genes c-fos ( 30 min ), c-myc ( 2 and 24 h ), and
H-ras ( 4 and 24 h ) ...
IGF-I or 10 % FCS, however, similarly
increased the mRNA late expression of c-myc,
H-ras , c-raf, beta-actin, and glucose 6-phosphate dehydrogenase (G6PD) at 72 h, as compared to quiescent cells