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AGRP — LEP

Text-mined interactions from Literome

Wilson et al., Endocrinology 1999 (Obesity...) : These results suggest that in the fed state, AGRP is normally suppressed by leptin , and that release of this suppression during fasting leads to increased ingestive behavior
Ebihara et al., Diabetes 1999 : We also studied leptin 's regulation of hypothalamic AGRP mRNA expression
Li et al., Endocrinology 2000 : In fasted animals leptin dose-dependently suppressed basal AGRP-LI release ... These studies demonstrate that in the rat there are different levels of basal hypothalamic AGRP-LI release in fed and fasted states and that in the fasted rat this release can be profoundly suppressed by leptin
Ahima et al., Regul Pept 2000 (Body Weight) : In contrast, leptin decreased body weight and adiposity, increased CART and suppressed NPY and AGRP mRNA expression in adult mice
Hidaka et al., J Neurochem 2001 (Diabetes Mellitus, Experimental...) : We proceeded to analyze whether insulin or leptin played the greater role in the regulation of AGRP using Zucker fa/fa rats
Korner et al., J Neuroendocrinol 2001 (Body Weight...) : Leptin regulation of Agrp and Npy mRNA in the rat hypothalamus
Tsuruta et al., Am J Physiol Endocrinol Metab 2002 (Body Weight...) : The effects of leptin on cocaine- and amphetamine regulated transcript ( CART ) and agouti related protein (AGRP) expression in the hypothalamic arcuate nucleus of obese A ( y ) /a mice were investigated
Hoggard et al., J Mol Endocrinol 2004 (Obesity...) : Additionally leptin inhibits release of agouti related protein (AgRP) , an MC4R antagonist
Breen et al., Brain Res 2005 : Agouti related protein (AGRP) and proopiomelanocortin (POMC) have opposing effects on melanocortin receptor ( MC-R ) signaling and energy balance, and are important targets for leptin and insulin in the hypothalamus ... Here we have examined the effects of fasting, leptin , and insulin on the release of AGRP and the POMC derived peptide gamma ( 3 ) -MSH from the perifused rat hypothalamus in vitro
Crowley et al., Neuroscience 2005 : In saline treated, SF controls, NPY and AgRP mRNA expression in arcuate nucleus and serum ghrelin were significantly elevated, and serum leptin and insulin were significantly reduced
Morrison et al., Am J Physiol Endocrinol Metab 2005 : Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling ... To investigate their role in leptin mediated inhibition of hypothalamic neuropeptide Y (Npy) and agouti related peptide (Agrp) gene expression, male Sprague-Dawley rats ( n = 5/group ) were either fed ad libitum or subjected to a 52-h fast ... We conclude that leptin requires intact PI3K signaling both to inhibit hypothalamic Npy and Agrp gene expression and activate neurons within the PVN
Pourtau et al., Brain Behav Immun 2011 (Body Weight...) : These findings indicate that blunted hypothalamic AgRP mRNA expression, probably as a consequence of relatively high leptin and low ghrelin concentrations, and reduced ventral striatal prostaglandin D synthesis play a role in maintaining cancer associated anorexia
Warne et al., J Neurosci 2013 (Fatty Liver...) : Furthermore, the suppressive effects of leptin on fasting induced hepatic steatosis are absent in mice lacking the gene encoding agouti related protein (Agrp), suggesting that this function of leptin is mediated by AGRP
Tritos et al., Endocrinology 1998 (Obesity) : In ob/ob mice, leptin deficiency results in increased expression of neuropeptide Y (NPY), agouti related protein (AGRP) , and melanin concentrating hormone ( MCH ), and decreased expression of POMC
Rosenfeld et al., Biochemistry 1998 : The hypothalamic expression of Agrp is regulated by leptin , and overexpression of Agrp in transgenic animals results in obesity and diabetes