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ICAM1 — IRF6

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Chakravortty et al., Biochim Biophys Acta 1999 : LPS induced ICAM expression in lamina propria fibroblasts was modulated by whole blood, PBMC and neutrophils
Liu et al., Mol Pharmacol 1999 (Shock, Septic) : These results demonstrate that NF-kappaB activation is an important in vivo mechanism mediating LPS induced CINC and ICAM-1 expression, as well as neutrophil recruitment, and the subsequent organ injury
Morise et al., Inflammation 1999 : Constitutive and LPS stimulated expression of intercellular adhesion molecule (ICAM)-1 , vascular cell adhesion molecule (VCAM)-1 and E-selectin were measured in wild type C57BL/6 and IL-10 deficient mice with no signs of active enterocolitis, using the dual radiolabeled monoclonal antibody technique ... However, we demonstrated larger increments in LPS induced expression of ICAM-1 and VCAM-1 in the vasculature of the small intestine in IL-10 deficient mice compared to WT mice ... These findings suggest that endogenous IL-10 does not modulate constitutive or LPS induced expression of ECAMs in most tissues, however it does appear to play an inhibitory role in LPS stimulated expression of ICAM-1 and VCAM-1 in the intestinal vasculature
McGilvray et al., Can J Surg 1999 (Dermatitis...) : Both ICAM-1 and VCAM-1 were upregulated in response to LPS ; however, only the increase in VCAM-1 was attenuated by antioxidant pretreatment
Wanner et al., Langenbecks Arch Surg 1999 (Endotoxemia) : To further clarify the underlying mechanisms, rG-CSF treated liver cells were tested for the LPS induced gene expression of cytokine induced neutrophil chemoattractant ( CINC ) and intercellular adhesion molecule-1 ( ICAM-1 ) as potential chemotactic and leukocyte recruiting factors and for the gene expression of inducible nitric oxide synthase ( NOS II ) as potential modulator of leukocyte adherence ... rG-CSF per se did not affect NOS II, CINC, or ICAM-1 expression in hepatic liver cells, while LPS induced a marked expression of NOS II, CINC, and ICAM-1 in nonparenchymal cells and, to a lesser extent, in hepatocytes
Masaka et al., J Periodontol 1999 (Periodontitis) : We investigated whether or not lipopolysaccharide (LPS) derived from the periodontopathic bacterium Porphyromonas gingiualis affects ICAM-1 expression on human gingival fibroblasts (HGF) ... P. gingivalis LPS induced ICAM-1 on HGF in a dose dependent manner in the presence of either 10 % fetal calf serum or 2 % NHS ... The ability of P. gingivalis LPS to induce ICAM-1 was comparable to that of LPS from E. coli at high LPS concentrations ... The ICAM-1 expression induced by P. gingivalis LPS was inhibited by a monoclonal antibody to CD14 ... These results indicate that P. gingivalis LPS induces ICAM-1 expression in HGF in an sCD14 dependent manner
Liu et al., Circulation 1999 (Shock, Septic) : Conclusions-NF-kappaB activation correlates with LPS induced expression of TNF-alpha, COX-2, CINC, and ICAM-1 genes in vivo
Takeuchi et al., Biochem Biophys Res Commun 2000 : We investigated the effect of cerivastatin on lipopolysaccharide (LPS) induced intercellular adhesion molecule-1 ( ICAM-1 ) expression in bovine aortic endothelial cells ... Cerivastatin suppressed LPS induced ICAM-1 mRNA expression ... Because Rho undergoes geranylgeranyl modification, we elucidated whether Rho is involved in LPS induced ICAM-1 expression ... Inhibition of Rho activity by Clostridium botulinum C3 transferase or by overexpression of RhoA T19N, a dominant negative mutant of RhoA, decreased LPS induced ICAM-1 expression ... The present results indicate that cerivastatin prevents LPS induced ICAM-1 expression in endothelial cells via inhibition of Rho activity
Fakler et al., Inflamm Res 2000 : Lung intercellular adhesion molecule-1 ( ICAM-1 ) expression is increased by LPS or hyperoxia on type II cells in vivo
Zacharowski et al., Arterioscler Thromb Vasc Biol 2000 (Myocardial Infarction...) : LPS also caused an upregulation of the expression of intercellular adhesion molecule-1 and P-selectin, whereas LTA downregulated these molecules and attenuated the accumulation of polymorphonuclear granulocytes caused by myocardial ischemia/reperfusion
Tummala et al., J Mol Cell Cardiol 2000 : DPI also inhibited TNF and LPS induced VCAM-1 and ICAM-1 cell surface expression and TNF- alpha, LPS , or IL-1 beta induced VCAM-1 and ICAM-1 mRNA accumulation
Heinzelmann et al., Immunopharmacology 2000 : On monocytes, LPS and MDP increased surface expression of human leukocyte antigen-DR ( HLA-DR ), CD18, CD54 ( intercellular adhesion molecule-1, ICAM-1 ), and CD86 ( B7-2 )
Baveye et al., Infect Immun 2000 : In a second step, we have investigated whether the capacity of hLf to interact with sCD14 could modulate the expression of endothelial-leukocyte adhesion molecule 1 ( E-selectin ) or intercellular adhesion molecule 1 ( ICAM-1 ) induced by the sCD14-LPS complex on human umbilical vein endothelial cells ( HUVEC )
Parmely et al., Infect Immun 2001 (Escherichia coli Infections) : Exogenous IFN-gamma restored iNOS and ICAM-1 responses to LPS in stressed mice
Marino et al., J Neuroimmunol 2001 : Membrane ICAM-1 and mRNA expression are absent under basal conditions, but can be induced by IFN-gamma, IL-1beta, IL-4, LPS and IL-6 with different efficiencies and time-courses
Noguchi et al., Inflammation 2001 (Periodontitis) : PGE2 significantly inhibited A. actinomycetemcomitans-, P. gingivalis- and E. coli-LPS induced ICAM-1 expression ... Our data suggest that PGE2 downregulates A. actinomycetemcomitans- and P. gingivalis-LPS induced ICAM-1 expression in HGF, via EP2/EP4 receptors by cAMP dependent signaling pathways
Van Kampen et al., Vet Immunol Immunopathol 2001 : Stimulation with LPS induced a significant increase in ICAM-1 mRNA expression between 1 and 12h after which the amounts rapidly decreased to baseline
Cerwinka et al., Shock 2001 (Hypercholesterolemia) : However, hypercholesterolemia enhanced LPS induced expression of P-selectin, E-selectin, and ICAM-1 in several vascular beds, while VCAM-1 expression was unaffected
Yan et al., Zhonghua Shao Shang Za Zhi 2001 : [ The role of p38 MAPK in LPS induced ICAM-1 expression on endothelial cell ] ... LPS could regulate the expression of ICAM-1 gene and protein in HUVEC by activating p38 MAPK signal transduction passage
Bessa et al., Gastroenterology 2002 (Colonic Neoplasms) : Neither baseline nor LPS induced endothelial ICAM-1 , P-, and E-selectin expression in tumors were reduced with respect to nontumor vasculature
Yan et al., Shock 2002 (Shock, Septic) : In vivo studies, administration of SB203580 ( 12.5 or 25 mg/kg, per ora ) markedly reduced LPS induced expression of ICAM-1 protein and mRNA of lung tissues of male BALB/c mice
Wirjatijasa et al., J Neurosci Res 2002 : Flow cytometry showed that lipopolysaccharide (LPS) induced ICAM-1-expression on microglial cells was strongly suppressed by ACM, significantly modulated by IL-4, IL-10, or IL-1-ra, but not influenced by TGF-beta
Ishida et al., J Immunol 2002 (Inflammation) : Furthermore, LPS induced ICAM-1 up-regulation was decreased by hypoxia
Powers et al., Surgery 2002 (Respiratory Distress Syndrome, Adult...) : The LPS induced ICAM-1 endothelial cell protein expression was also prevented with A25 resuscitation
Zeuke et al., Cardiovasc Res 2002 (Heart Failure) : FACS analysis showed an LPS induced upregulation of ICAM-1 , VCAM, and ELAM-1
Banu et al., Exp Nephrol 2002 : These studies demonstrate normal patterns of class II MHC, ICAM-1 , and B7 expression in TGF-beta1 ( -/- ) tubular epithelial cells in response to IFN-gamma, LPS , and TGF-beta1
Panther et al., Blood 2003 : Adenosine also increased LPS induced CD54 , CD80, MHC class I, and HLA-DR molecule expression in mDCs
Scholzen et al., Endocrinology 2003 (Vasculitis) : In HDMEC, alpha-MSH ( 10 ( -8 ) /10 ( -12 ) M ) profoundly reduced the mRNA and protein expression of E-selectin, vascular CAM (VCAM)-1, and intercellular CAM (ICAM)-1 induced by LPS or TNFalpha as determined by semiquantitative RT-PCR, ELISA, and fluorescence activated cell sorter analysis ... In addition, alpha-MSH significantly impaired the LPS induced ICAM-1 and VCAM-1 mediated adhesion of lymphocytes to HDMEC monolayer in a functional adhesion assay
Shan et al., Zhonghua Shao Shang Za Zhi 2002 : [ The significance of the expression of endothelial ICAM-1 induced by LPS ] ... To investigate the significance of the expression pattern and its signal modulating mechanism of endothelial ICAM-1 induced by LPS ... ( 1 ) The ICAM-1 mRNA expression could be induced by LPS ( 100 pg/ml ) for 6 hours, and the expression was enhanced along with the increase of LPS concentration ... The ICAM-1 mRNA expression of HUVECs could be induced by LPS in both dose and time dependent manner
Cuschleri et al., Shock 2003 (Inflammation) : Actin depolymerization also significantly inhibited LPS induced ICAM-1 and IL-8 production
Rafiee et al., Am J Physiol Gastrointest Liver Physiol 2003 (Esophagitis) : TNF-alpha/LPS activation of HEMEC resulted in upregulation of the cell adhesion molecules (CAM) ICAM-1 , VCAM-1, E-selectin, and mucosal addressin CAM-1 (MAdCAM-1), increased IL-8 production, and enhanced leukocyte binding
Myers et al., Am J Physiol 1992 : We conclude from these data that although PMA induced ICAM-1 expression may be triggered through activation of protein kinase C, ICAM-1 induction by IL-1 beta, TNF-alpha, or LPS may involve distinct regulatory pathway ( s )
Wong et al., J Neuroimmunol 1992 : Stimulation with LPS and cytokines induces upregulation of ICAM-1 which is minimal with IFN-gamma and maximal with LPS or a combination of IFN-gamma and TNF-alpha
Myers et al., Am J Physiol 1992 : Induction of ICAM-1 by TNF-alpha, IL-1 beta, and LPS in human endothelial cells after downregulation of PKC ... The intercellular adhesion molecule 1 ( ICAM-1 ) is induced on endothelial cells by tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), and lipopolysaccharide (LPS)
Ren et al., Yao Xue Xue Bao 2003 : Lipopolysaccharide (LPS) increased ICAM-1 expression in HUVEC in a concentration- and time dependent manner
Zielinski et al., Breast Cancer Res Treat 2003 (Breast Neoplasms) : We conclude that the presence of germline mutations of BRCA1 was associated with a selective deficiency in spontaneous and LPS induced production of TNF-alpha and of TNF-alpha induced ICAM-1 expression on peripheral blood monocytes
Madan et al., J Ethnopharmacol 2003 (Edema) : Schult ( Gentianaceae ) inhibits LPS induced expression of ICAM-1 and E-selectin on endothelial cells and carageenan induced paw-edema in rats ... Our results demonstrated that treatment of human endothelial cells with the extract down-regulated the LPS induced expression of ICAM-1 and E-selectin
Lee et al., J Immunol 2004 : The LPS induced increase in the expression of ICAM-1 on A549 cells correlated with TNF production by PBMC
Xiao et al., Yao Xue Xue Bao 2003 : Moreover, LPS induced high expression of ICAM-1 and CD18 was inhibited with treatment of EsA
Bruey et al., J Biol Chem 2004 : Conversely, reducing endogenous levels of PAN1 using small interfering RNA enhanced LPS induced production of ICAM-1 ( intercellular adhesion molecule 1 ), an NF-kappaB dependent gene
Nakahara et al., Int Immunol 2004 : SP600125, a specific inhibitor of JNK, inhibited the LPS induced up-regulation of CD80, CD83, CD86 and CD54 , but augmented the up-regulation of HLA-DR. SP600125 slightly inhibited the down-regulation of FITC-dextran uptake during DC maturation
Kumagai et al., Invest Ophthalmol Vis Sci 2005 : The expression of ICAM-1 at the surface of corneal fibroblasts and the amount of ICAM-1 mRNA in the cells were both increased by LPS
Wu et al., Am J Physiol Heart Circ Physiol 2005 : Inhibitor studies in endothelial cells demonstrated a critical role for PKC in mediating thrombin, TNF-alpha, and LPS induction of ICAM-1 , TF, and u-PA and for p38 MAPK in mediating thrombin, TNF-alpha, and LPS induction of TF
Szászi et al., Free Radic Biol Med 2005 : The present studies were performed to discern the mechanism whereby DEM prevents LPS induced ICAM-1 expression in human umbilical vein endothelial cells ... Readdition of glutathione following DEM treatment restored the ability of LPS to induce NF-kappaB translocation and ICAM-1 synthesis
Lo et al., J Ethnopharmacol 2005 (Pulmonary Edema) : Western blotting analysis results indicated that all of them significantly inhibited LPS induced iNOS, TGF-beta, p38MAPK, and ICAM-1 expressions in the lung tissues
Kim et al., Immunology 2005 : We report that luteolin significantly blocks lipopolysaccharide (LPS) induced IkappaB phosphorylation/degradation, NF-kappaB transcriptional activity and intercellular adhesion molecule-1 ( ICAM-1 ) gene expression in rat IEC-18 cells
Kim et al., Clin Exp Immunol 2005 (Translocation, Genetic) : We report that SME significantly abrogated LPS induced IkappaB phosphorylation/degradation, NF-kappaB transcriptional activity and ICAM-1 gene expression in rat IEC-18 cells
Zhang et al., Zhongguo Zhong Yao Za Zhi 2005 : l-THP ( 250 mg x L ( -1 ) ) markedly attenuated ICAM-1 and E-selectin expression induced by LPS ( P < 0.05 ). l-THP ( 50 mg x L ( -1 ) inhibited E-selectin expression ( P < 0.05 ) but had no effect on ICAM-1 ( P > 0.05 ). l-THP ( 10 mg x L ( -1 ) ) had no effect on expression of both adhesion molecules ... l-THP depresses expression of ICAM-1 and E-selectin induced by LPS , which suggests that I-THP represent a promising candidate to be developed into therapies for the treatment of inflammation
Fukuda et al., Invest Ophthalmol Vis Sci 2005 : However, sCD14 or LBP enhanced the LPS induced upregulation of ICAM-1 and the chemokines interleukin-8 and monocyte chemoattractant protein (MCP)-1 in these cells at the protein and mRNA levels
Mazzola et al., FASEB J 2005 (Disease Models, Animal...) : Lastly, CO pretreatment prevents LPS induced ICAM expression on lung endothelium and inhibits leukocyte marginalization on lung parenchyma
Duan et al., J Ethnopharmacol 2006 : We investigated the effect of anemonin on the release of nitric oxide ( NO ), endothelin-1 (ET-1) and soluble intercellular adhesion molecule-1 ( sICAM-1 ) induced by lipopolysaccharide (LPS) in primary cultures of rat intestinal microvascular endothelial cells ( RIMECs )
Jeyaseelan et al., J Immunol 2005 (Escherichia coli Infections...) : LPS induced neutrophil sequestration ; NF-kappaB translocation ; keratinocyte cell derived chemokine, MIP-2, TNF-alpha, and IL-6 expression ; histopathology ; and VCAM-1 and ICAM-1 expression were abolished in the lungs of TIRAP-/- mice
Chanchevalap et al., Nucleic Acids Res 2006 : The induction of ICAM-1 expression and T cell adhesion to IEC6 by LPS were both abrogated by siRNA inhibition of KLF5
Waldow et al., Nitric Oxide 2006 : The induction of vascular cell adhesion molecule ( VCAM ), intercellular adhesion molecule ( ICAM ) and E-selectin by the cytokines TNFalpha and IL-1beta, and by bacterial lipopolysaccharide (LPS) was reduced by SNAP/Cys preincubation ( 30 min, 1mM ) to less than 10 % of controls
Takahashi et al., J Antibiot (Tokyo) 2006 : We confirmed that surfactin inhibited LPS induced expression of ICAM-1 and VCAM-1 in HUVEC
Dal Secco et al., Nitric Oxide 2006 : Moreover, genetic ( iNOS-/- mice ) or pharmacological inhibition of NOS or of sGC enhanced LPS induced ICAM-1 expression on mesenteric microcirculation vessels of WT mice
Orrington-Myers et al., Am J Physiol Lung Cell Mol Physiol 2006 : In addition, DeltaEXD transfection suppressed LPS induced activation of NF-kappaB and consequent ICAM-1 expression
Lucchi et al., J Reprod Immunol 2007 : LPS induced time dependent expression and secretion of IL-8, macrophage inflammatory protein (MIP)-1alpha and MIP-1beta from ST cells and an upregulation of ICAM-1
Lu et al., Invest Ophthalmol Vis Sci 2006 : Lipopolysaccharide (LPS) induced the release of the proinflammatory cytokine IL-6 and that of the chemokines G-CSF, MCP-1, MIP-1beta, and IL-8 as well as surface expression of ICAM-1 by corneal fibroblasts, whereas IL-1beta, TNF-alpha, and GM-CSF were not detected in the culture supernatants of cells incubated with or without LPS ... Both compounds inhibited the LPS induced surface expression of ICAM-1 ... Triptolide inhibits the LPS induced expression of IL-6, chemokines ( G-CSF, MCP-1, IL-8 ), and ICAM-1 in cultured human corneal fibroblasts
Kim et al., Exp Mol Med 2006 (Encephalitis) : To elucidate the roles of 8-hydroxydeoxyguanosine ( oh ( 8 ) dG ), the nucleoside of 8-hydroxyguanine ( oh ( 8 ) Gua ), we examined the effects of oh ( 8 ) dG upon LPS induced intercellular adhesion molecule-1 ( ICAM-1 ) expression and the underlying mechanisms in brain microglial cells
Arenas et al., Int J Radiat Oncol Biol Phys 2006 (Inflammation) : LPS induced ICAM-1 upregulation was not modified by LD-RT. Circulating levels of TGF-beta1 were significantly increased in response to LD-RT in controls and LPS challenged animals
Cheng et al., J Surg Res 2006 (Endotoxemia...) : In subsequent experiments, lipoproteins were extracted from NML before incubation and LPS induced ICAM-1 expression determined ... Lipoproteins in NML contain anti-inflammatory properties that decrease ICAM-1 expression induced by LPS in pulmonary endothelium ... Mean fluorescent intensity ( MFI ) of LPS induced ICAM-1 in NML and PSML treated HMVECs were 10.1 +/- 2.3 versus 27.7 +/- 0.83, respectively ( P < 0.05 ). This represented at 71 % decrease in ICAM-1 expression by NML compared to ICAM-1 expression in LPS induced controls ( MFI : 34.6 +/- 6.9 ). Lipoprotein extraction from NML abolished this protective effect ( MFI : 31.2 +/- 5.3 versus Control + LPS : 33.5 +/- 3.6, P > 0.05 )
Park et al., Cardiovasc Res 2006 (Bacterial Infections) : Downregulation of Nox4 by transfection of siRNA specific to Nox4 in HAECs resulted in a failure to induce reactive oxygen species ( ROS ) generation and subsequent expression of intercellular adhesion molecule-1 ( ICAM-1 ) and chemokines such as IL-8 and monocyte chemoattractant protein-1 ( MCP-1 ) in response to LPS
Zhang et al., Am J Nephrol 2006 : This study was to investigate the expression of PPARgamma in rat PMCs and the effect of PPARgamma activation on the production of CD40 and ICAM-1 induced by lipopolysaccharide (LPS) ... There is constitutive expression of PPARgamma in cultured RPMCs and PPARgamma ligands which strongly inhibit LPS induced CD40 and ICAM-1 production in RPMCs
Liu et al., Life Sci 2007 : In our present study, we have demonstrated chalcone inhibited IL-6- and LPS induced ICAM-1 gene expression
Ao et al., Cytokine 2007 (Endotoxemia...) : The purpose of this study was to determine : whether ICAM-1 knockout improves cardiac function during endotoxemia and whether TLR4 and TNF-alpha regulate LPS induced myocardial ICAM-1 expression
Singh et al., Phytomedicine 2008 : The major CAMs, viz., intercellular adhesion molecule-1 ( ICAM-1 ), VCAM-1 and E-selectin are expressed on endothelium in response to various cytokines or bacterial LPS ... The major CAMs, viz., intercellular adhesion molecule-1 ( ICAM-1 ), VCAM-1 and E-selectin are expressed on endothelium in response to various cytokines or bacterial LPS
Hamano et al., Shock 2008 : Stimulation of adenosine A2A receptor inhibits LPS induced expression of intercellular adhesion molecule 1 and production of TNF-alpha in human peripheral blood mononuclear cells ... We found that adenosine inhibited the expression of ICAM-1 and the production of TNF-alpha by human PBMC via adenosine A2A receptor in the presence of LPS
Das et al., J Biomed Mater Res A 2008 : Expression of ICAM-1 ( intercellular adhesion molecule ), a key molecule in DC-T cell interaction was increased in mature DCs in response to lipopolysaccharide (LPS)
Sawa et al., J Histochem Cytochem 2008 : The LPS induced IL-6, IL-8, VCAM-1, and ICAM-1 production in LEC was suppressed by the introduction of TLR4-specific small interfering RNA, and also by anti-TLR4, nobiletin, and CAPE pretreatment
Sun et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2007 : To investigate the inhibitory effects of anisodamine ( 654-2 ) and pentoxifylline ( PTX ) on the expression of lipopolysaccharide (LPS) induced intercellular adhesion molecule-1 ( ICAM-1 ) in rat cardiac muscle in vivo
Chen et al., Zhonghua Yi Xue Za Zhi 2007 (Burns) : LPS induces ICAM-1 expression, which can be inhibited by Pim-3
Xu et al., Immunology 2008 : Following LPS stimulation, up-regulation of the surface markers CD40, CD86, I-Ad, immunoglobulin M, CD54 and interleukin-10 production, accompanied by down-regulation of CD5 and CD184 ( CXCR4 ) were observed in a LPS dose dependent manner
Lee et al., J Endod 2008 (Pulpitis) : The purpose of this study was to determine the effects of terrein on lipopolysaccharide (LPS) induced expression of intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in human dental pulp cells and to determine the mechanism of the observed effects ... The LPS induced expression of ICAM-1 and VCAM-1 was inhibited by terrein in both a time- and dose dependent manner
Mayr et al., Shock 2008 (Endotoxemia...) : Finally, neither the LPS induced release of tumor necrosis factor, interleukin 6, leukocyte expression of CD11b, nor intercellular adhesion molecule 1 were affected by administration of bimosiamose
Lu et al., Int Immunopharmacol 2008 : In the presence of LPS , VIP also dose dependently up-regulated the expression of CD80, CD86, CD54 and CD40, and down-regulated the expression of Ia ( b )
Shen et al., FEBS J 2008 : It has been reported that, in the central nervous system, the expression level of intercellular adhesion molecule-1 ( ICAM-1 ) was dramatically upregulated in response to LPS , as well as many inflammatory cytokines
Swerlick et al., J Invest Dermatol 1991 : ICAM-1 , but not LFA-3 or CD44, was increased in expression in a dose- and time dependent manner by interleukin 1 (IL-1) alpha, tumor necrosis factor (TNF) alpha, lipopolysaccharide (LPS) , or interferon (IFN) gamma ... IL-1 alpha, TNF alpha, and LPS increased ICAM-1 expression on average 100-200 % whereas IFN gamma was somewhat less potent ... Pretreatment with dexamethasone or transforming growth factor ( TGF ) beta did not affect baseline expression of ICAM-1 or inhibit upregulation of ICAM-1 on HDMEC by IL-1 alpha, TNF alpha, LPS , or IFN gamma
Zou et al., Am J Physiol Heart Circ Physiol 2009 (Disease Models, Animal...) : LPS ( 2 microg/ml ) increased the levels of IkappaB-alpha phosphorylation, TNF-alpha, ICAM-1 , and NF-kappaB in primary cultured cardiomyocytes, which was significantly attenuated by glucosamine treatment and overexpression of O-GlcNAc transferase ; both interventions also significantly increased O-GlcNAc levels
Morimoto et al., Am J Physiol Lung Cell Mol Physiol 2009 (Bacterial Infections...) : We previously reported that E1A, a well-known regulator of host genes, increased ICAM-1 expression in human bronchial epithelial ( HBE ) and A549 cells in response to LPS stimulation
Eckhardt et al., Biomaterials 2009 : The LPS stimulated expression of CD54 ( ICAM-1 ) was increased about twofold by increasing TEGDMA concentrations after a 24 and 48h exposure
Kadl et al., Arthritis Rheum 2009 (Inflammation...) : LPS , but not OxPAPC, induced the expression of adhesion molecules E-selectin, P-selectin, intercellular adhesion molecule 1 , and vascular cell adhesion molecule 1
Suo et al., J Ethnopharmacol 2009 : Moreover, the effects of MT on soluble intercellular adhesion molecule-1 ( sICAM-1 ), interleukin-6 (IL-6) and interleukin-8 (IL-8) production induced by lipopolysaccharide (LPS) in these cells were evaluated
Song et al., J Surg Res 2011 (Aortic Valve Stenosis...) : We have previously shown that human AVICs express functional toll-like receptor 4 (TLR4), and express increased levels of ICAM-1 in response to stimulation with bacterial lipopolysaccharide (LPS) ... Pretreatment with the actin polymerization inhibitor latrunculin B and silencing a-actinin 1 with siRNA reduced LPS induced total and cell-surface ICAM-1 expression ... This study demonstrates that ( 1 ) LPS stimulated ICAM-1 expression in human AVICs is mediated by TLR4, ( 2 ) ICAM-1 interacts with microfilaments soon after LPS stimulation, and ( 3 ) microfilament disruption reduces ICAM-1 expression ... These results suggest that the interaction between ICAM-1 and microfilaments facilitates LPS induced ICAM-1 expression in human AVICs
Zhang et al., Br J Pharmacol 2009 : Ucn1 augmented LPS induced expression of COX-2 and ICAM-1 in RAECs in a time- and concentration dependent manner ... These findings suggest that Ucn1 exerts pro-inflammatory effects by augmenting LPS induced expression of COX-2 and ICAM-1 in RAECs via CRF ( 2 ) receptors and the activation of p38MAPK and NF-kappaB
Kim et al., Kidney Int 2009 (Acute Kidney Injury) : Treatment also mitigated the effects of LPS on renal intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 protein expression, the number of ER-HR3 positive macrophages that infiltrated the kidney, serum nitrate/nitrite levels, renal inducible nitric oxide synthase protein expression, the induction of tubular epithelial reactive oxygen and nitrogen species, and renal microvascular permeability
Lee et al., Int J Antimicrob Agents 2010 (Periodontal Diseases) : The neutralising effect of these AMPs on expression of interleukin (IL)-1beta, IL-8 and intercellular adhesion molecule 1 ( ICAM-1 ) induced by lipopolysaccharide (LPS) from P. intermedia and T. forsythia was also tested in THP-1 cells and human gingival fibroblasts ... However, all of the AMPs except HNP-2 at 5microM significantly inhibited the expression of IL-1beta, IL-8 and ICAM-1 induced by P. intermedia LPS
Zhang et al., Molecular vision 2009 : BOL-303242-X also significantly reduced LPS induced IL-1ss release and ICAM-1 levels in HRECs
Chen et al., Chin Med Sci J 2009 (Keratitis) : Furthermore, the activation of NF-kappaB and the expression of ICAM-1 induced by LPS were markedly inhibited in emodin group ... Emodin can inhibit the activation of NF-kappaB and the expression of ICAM-1 induced by LPS in corneas, protect against acute corneal injury, and improve symptoms in rats
Lubos et al., FASEB J 2010 : Knockdown of CD14 attenuated LPS mediated up-regulation of ICAM-1 and VCAM-1 mRNA and protein, and it mitigated the effects of GPx-1 deficiency on LPS induced adhesion molecule expression
Andreasen et al., Intensive Care Med 2010 (Diabetes Mellitus, Type 2...) : Type 2 diabetes was associated with less pronounced LPS induced increases in TNF, IL-1ra, VCAM-1 and ICAM-1
Lapointe et al., J Cell Physiol 2010 (Disease Models, Animal...) : Together, our data demonstrate the role of sPLA ( 2 ) -V in LPS induced ICAM-1 and VCAM-1 protein overexpression and leukocyte recruitment, supporting the contribution of sPLA ( 2 ) -V in the development of inflammatory innate immune responses
Tsutsumi et al., J Periodontal Res 2010 (Atherosclerosis) : The expressions of ICAM-1 and LFA-1 on the surface of RAW 264.7 cells increased following 12 h culture with LPS ; L-selectin expression was unaffected
Liu et al., Chin Med J (Engl) 2010 (Reperfusion Injury) : After treatment with 2 L/min of 250 ppm CO i.p., the increase of PAF, ICAM-1 , MDA, MPO, and cell apoptotic rate induced by LPS was markedly reduced ( P < 0.05 or 0.01 ), and accompanied by ameliorating intestine injury
Datla et al., Br J Pharmacol 2010 (Edema...) : Treatment with RSCL-0520 reduced LPS stimulated mRNA expression of TNF-alpha, COX-2, intercellular adhesion molecule-1 , interleukin (IL)-8 and IL-1beta, all regulated through NF-kappaB activation
Zerfaoui et al., J Immunol 2010 : Crm1 inhibition promoted p65 NF-kappaB nuclear accumulation as well as reversed LPS induced p65 NF-kappaB phosphorylation and inducible NO synthase and ICAM-1 expression
Song et al., Inflamm Res 2011 (MAP Kinase Signaling System) : Black tea polyphenol theaflavin suppresses LPS induced ICAM-1 and VCAM-1 expression via blockage of NF-?B and JNK activation in intestinal epithelial cells ... LPS induced ICAM-1 and VCAM-1 expressions were inhibited by theaflavin ... Bay11-7082 ( a NF-?B inhibitor ) and SP600125 ( a JNK inhibitor ) suppressed the LPS induced ICAM-1 and VCAM-1 mRNA accumulations ... These results indicate that black tea polyphenol theaflavin suppresses LPS induced ICAM-1 and VCAM-1 expressions through blockage of NF-?B and JNK activation in intestinal epithelial cells
Wang et al., J Immunol 2011 (Acute Lung Injury...) : Knockdown of p120 also increased the expression of ICAM-1 , neutrophil recruitment, production of cytokines TNF-a and IL-6, pulmonary transvascular protein permeability, and lung water content in response to LPS
Pan et al., Amino Acids 2011 (Inflammation) : In addition, SPRC attenuated LPS induced mRNA and protein expression of tumor necrosis factor-a (TNF-a), and mRNA expression of intercellular adhesion molecule-1 ( ICAM-1 ) and inducible nitric oxide synthase (iNOS)
Wei et al., Am J Physiol Heart Circ Physiol 2011 (Disease Models, Animal...) : Finally, TTM significantly inhibited LPS induced increases of serum levels of soluble ICAM-1 , MCP-1, and TNF-a ( ANOVA, P < 0.05 )
Mehla et al., J Ethnopharmacol 2011 : It significantly attenuated LPS induced ICAM-1 and VCAM-1 at the protein and mRNA levels
Fu et al., Mol Hum Reprod 2012 : Our findings show that all progestins significantly suppress endothelial expression of vascular cell adhesion molecule-1 ( VCAM-1 ) and inter-cellular adhesion molecule-1 ( ICAM-1 ) induced by bacterial lypopolysaccharide (LPS)
Wang et al., Zhongguo Zhong Yao Za Zhi 2011 : It has been observed by RT-PCR that HSYA can inhibit the elevation of TNF-alpha, IL-6, ICAM-1 and VCAM-1 mRNA level induced by LPS
van den Elsen et al., Am J Clin Nutr 2011 (Inflammation) : The level of ICAM-1 expression per cell [ ie, the median fluorescence intensity ( MFI ) ] was increased by LPS stimulation in the control group ( 16.9 ± 2.4 compared with 135.3 ± 20.2 ; P < 0.001 ) and to a lesser extent in the salmon group ( 14.1 ± 3.8 compared with 65.8 ± 22.4 ; P = 0.037 )
Han et al., BMC complementary and alternative medicine 2011 (Disease Models, Animal...) : Treatment with FSE significantly inhibited LPS induced increases in IL-1ß and TNF-a production and the expression of iNOS, ICAM-1 and COX-2 ... Treatment with FSE significantly inhibited LPS induced increases in IL-1ß and TNF-a production and the expression of iNOS, ICAM-1 and COX-2
Michielsen et al., PloS one 2011 (Colorectal Neoplasms) : Pre-treatment of monocyte derived dendritic cells with this tumour conditioned media inhibited the up-regulation of CD86, CD83, CD54 and HLA-DR in response to LPS , enhancing IL-10 while reducing IL-12p70 secretion ... Pre-treatment of immature dendritic cells with VEGF inhibited LPS induced upregulation of CD80 and CD54 , while CXCL1 inhibited HLA-DR. Interestingly, treatment of dendritic cells with CCL2, CXCL1, CXCL5 or VEGF significantly suppressed their ability to secrete IL-12p70 in response to LPS
Qureshi et al., Lipids in health and disease 2011 (Inflammation...) : The microarray DNA analyses, followed by pathway analyses indicated that quercetin or d-tocotrienol inhibit several LPS induced expression of several ageing and pro-inflammatory genes ( IL-1ß, IL-1a, IL-6, TNF-a, IL-12, iNOS, VCAM1, ICAM1 , COX2, IL-1RA, TRAF1 and CD40 ) ... The microarray DNA analyses, followed by pathway analyses indicated that quercetin or d-tocotrienol inhibit several LPS induced expression of several ageing and pro-inflammatory genes ( IL-1ß, IL-1a, IL-6, TNF-a, IL-12, iNOS, VCAM1, ICAM1 , COX2, IL-1RA, TRAF1 and CD40 )
Han et al., Inflammation 2012 (Inflammation...) : AGF at the dose level of 500 mg/kg significantly inhibited LPS induced upregulation of NF-?B activation and the production of IL-1ß, TNF-a, iNOS, ICAM-1 , and COX-2
Kandasamy et al., Microvasc Res 2012 : In situ immunofluorescence experiments revealed that LPS significantly increased microvessel ICAM-1 expression at 90 min post treatment ... Taken together, the data suggest that LPS increased leukocyte retention in both venules and capillaries and this response was mediated by the increased expression of endothelial ICAM-1
Joo et al., Gut and liver 2012 : U0126 ( an inhibitor of MEK-1/2 ) suppressed the LPS induced IL-12p40, IL-6, MCP-1, ICAM-1 , and VCAM-1 mRNA accumulation in BMMs
Lalu et al., J Cardiovasc Pharmacol 2012 (Inflammation) : LPS increased total content and cell surface expression of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 , whereas proteasome inhibition ameliorated these increases
Peng et al., Acta Biochim Biophys Sin (Shanghai) 2012 (Inflammation) : TLR4 inhibition reduced LPS induced upregulation of inducible nitric oxide synthase (iNOS) and ICAM-1 as well as PARP1 ... Our study demonstrated that LPS increased ICAM-1 and iNOS expression via TLR4/PARP1/NF-?B pathway
Jiang et al., Microcirculation 2013 (MAP Kinase Signaling System) : Dextromethorphan inhibits the adhesive capacity of HUVECs by reducing the LPS induced ICAM-1 and VCAM-1 expression via the suppression of the ERK, Akt, and NF-?B signaling pathways
Miyazaki et al., BMC nephrology 2012 (Acute Kidney Injury) : T-5224 also inhibited LPS induced ICAM-1 mRNA expression
Wu et al., Int J Immunopathol Pharmacol 2012 (Liver Failure, Acute) : In addition, pretreatment mice with PD dose-dependently suppressed tumor necrosis factor-alpha (TNF-alpha) production, myeloperoxidase (MPO) activity, intercellular adhesion molecule-1 ( ICAM-1 ) and endothelial cell adhesion molecule-1 ( ECAM-1 ) expression, caspase-3 activation, and transcription factor nuclear factor-kappa B(NF-kB) activity induced by LPS
Menden et al., Am J Physiol Lung Cell Mol Physiol 2013 : LPS induced expression of intercellular adhesion molecule 1 ( ICAM-1 ) was associated with increased 2-OH-E ( + ) ( marker for superoxide formation ) levels and was attenuated by apocynin and the Nox inhibitor, VAS2870 ... Silencing Nox2, but not Nox4, suppressed LPS induced ICAM-1 expression in HPMEC ... LPS increased PP2A activity in HPMEC, and inhibition of PP2A did not alter LPS mediated ICAM-1 expression but attenuated IKK-ß phosphorylation ... TAK1 inhibition decreased LPS induced ICAM-1 expression in HPMEC, and Nox2 silencing attenuated LPS mediated TAK1 phosphorylation ( Thr184/187 )
Lin et al., Shock 2013 (Acute Lung Injury) : In addition, LPS increased pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor a and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhanced the expression of E-selectin, intercellular adhesion molecule 1 , myeloperoxidase, MMP-2, and MMP-9, whereas it decreased the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which were attenuated by SalB pretreatment
Xu et al., Molecular vision 2013 (Inflammation...) : Our results suggested that GC31 suppressed LPS mediated ICAM-1 expression by inhibiting the activation of NF-?B and partially by attenuating the activity of ERK1/2 and p38 MAPK in vascular endothelium, which may contribute to ameliorating vascular inflammatory diseases, such as uveitis
Cho et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2013 : LPS increased VCAM-1 and ICAM-1 expression ... Ginsenoside Rg2 prevented LPS mediated increase of VCAM-1 and ICAM-1 expression
Yang et al., J Immunol 1994 (Sarcoma, Kaposi...) : ICAM-1 , VCAM-1, and E-selectin were all induced by dsRNA ( poly ( I:C ) ), IL-1 beta, TNF-alpha, and LPS in KS cells
Repo et al., Scand J Immunol 1994 : Alkali treated LPS of Yersinia enterocolitica does not induce expression of E-selectin, ICAM-1 or VCAM-1 on endothelial cells but may mediate antibody- and complement dependent cell injury ... Alkali treated LPS of Yersinia enterocolitica does not induce expression of E-selectin, ICAM-1 or VCAM-1 on endothelial cells but may mediate antibody- and complement dependent cell injury ... Studies of the mechanism underlying the poor augmentation revealed that neither enzymatically deacylated LPS from Escherichia coli J5 ( J5 dLPS ) nor yersinia LPS-OH stimulated expression of endothelial cell adhesion molecules E-selectin, VCAM-1 and ICAM-1 , whereas both intact J5 LPS and yersinia LPS were stimulatory
Leeuwenberg et al., Cytokine 1995 : In contrast, both MR2-1 and pAb75 inhibited specifically TNF induced E-selectin and ICAM-1 expression, but not activation by IL-1 or LPS
van Oosten et al., Hepatology 1995 (Shock, Septic) : Stimulation with LPS increased the expression of ICAM-1 2.5 times per parenchymal cells and approximately 4 times for endothelial and Kupffer cells
Shrikant et al., J Immunol 1995 : We demonstrated previously that three proinflammatory cytokines, TNF-alpha, IL-1 beta, and IFN-gamma, as well as IFN-gamma plus LPS , can enhance ICAM-1 expression by primary rat astrocytes
Matsuda et al., Int Arch Allergy Immunol 1995 (Encephalomyelitis, Autoimmune, Experimental...) : LPS enhanced ICAM-1 expression on endothelial cells and lymphocyte adhesion to those cells, and caused a significant increase in the in vivo expression of ICAM-1 compared with controls ( p < 0.001 )
Nitta et al., Nihon Jinzo Gakkai Shi 1995 (Glomerulonephritis) : LPS was the most potent inducer of ICAM-1 molecule expression on GEN
Rieckmann et al., Neurosci Lett 1995 : Stimulation of confluent monolayers of adult human cerebral endothelial cells with lipopolysaccharide (LPS) or recombinant human tumor necrosis factor-alpha (TNF-alpha) could induce expression and secretion of soluble ICAM-1 in a dose dependent manner
Eissner et al., Scand J Immunol 1994 : We found that tumour necrosis factor alpha (TNF-alpha)- and lipopolysaccharide (LPS) induced ICAM-1 expression on a human endothelium derived cell line ( EA.hy926 ) were unaffected by the PKC-inhibitor and thus appeared to be independent of PKC activation
Pang et al., Clin Exp Immunol 1994 : Finally, both LPS and IL-1 alpha up-regulated ICAM-1 and VCAM-1 gene expression
Goebeler et al., Immunobiology 1993 (Inflammation) : Furthermore, ICAM-1 expression by bone marrow derived M phi could be up-regulated by tumor necrosis factor-alpha, interferon-gamma and LPS
Maier et al., Exp Cell Res 1993 (Arteriosclerosis) : Here we show that ( i ) senescence enhances monoblastoid U937 cell adhesion to the endothelial monolayer ; ( ii ) the enhanced interaction between senescent endothelial cells and U937 cells is mediated , at least in part, by the overexpression of ICAM-1 ; and ( iii ) LPS and interleukin 1 alpha, but not tumor necrosis factor alpha, are unable to stimulate the adhesion of U937 to senescent endothelial cells
Schmittel et al., Scand J Immunol 1995 : ICAM-1 and HLA-DR were up-regulated by IFN-gamma and LPS ; LFA-3 expression was not influenced
Seitz et al., Lab Invest 1996 : Increased coordinated LPS dependent expression of hsp60 and ICAM-1 correlates with monocyte and T-cell adhesion to aortic endothelium
Drescher et al., J Neuroimmunol 1996 : Bacterial lipopolysaccharide (LPS) , a known stimulator of central nervous system ( CNS ) astrocytes, increased ICAM-1 expression only 3-fold to 9 % of cells staining positively, but neither MHC Class I nor Class II expression was altered from baseline levels
Sakai et al., Life Sci 1996 : Pretreatment of diclofenac inhibited LPS induced expression of E-selectin, intercellular adhesion molecule-1 ( ICAM-1 ) and vascular cell adhesion molecule-1 ( VCAM-1 ) in HUVEC, determined by flow cytometry and a cellular enzyme linked immunosorbent assay ( cell-ELISA ) ... The inhibitory activity was concentration dependent between 15.6 and 250 micrograms/ml. Diclofenac also inhibited LPS induced increases in E-selectin, ICAM-1 and VCAM-1 mRNAs, indicating that the action of diclofenac is to inhibit synthesis of these molecules
Sakai et al., Inflamm Res 1996 : Pretreatment of SJC13 inhibited LPS induced expression of E-selectin and vascular cell adhesion molecule-1 ( VCAM-1 ), but not intercellular adhesion molecule-1 ( ICAM-1 ), in HUVEC, determined by flow cytometry and cellular enzyme linked immunosorbent assay ( cell-ELISA )
Shrikant et al., J Immunol 1996 (Astrocytoma) : We previously demonstrated that TNF-alpha, IL-1 beta, IFN-gamma, or IFN-gamma plus LPS ( IFN-gamma/LPS ) can enhance ICAM-1 expression in astrocytes, while microglia express ICAM-1 only in response to IFN-gamma or IFN-gamma/LPS ... Interestingly, TGF-beta has no effect on IFN-gamma- or IFN-gamma/LPS induced ICAM-1 expression in astrocytes or microglia
Burke-Gaffney et al., Am J Physiol 1996 : LPS induced ICAM-1 expression was not inhibited by interleukin-1 (IL-1) receptor antagonist ( 0.01-100 micrograms/ml ) ... In contrast, dexamethasone dose dependently ( 0.1-1,000 nM ) inhibited LPS induced ICAM-1 expression ; however, its effect on mRNA was not established, because ICAM-1 mRNA induced by LPS was not detected at the time points investigated in this study ( 3 and 20 h )
Eissner et al., Transplantation 1996 : Recombinant human interleukin 10 (IL-10), an antagonistic cytokine known to function as an LPS antagonist, was able to counteract the LPS mediated enhancement of IR-triggered ICAM-1 induction and PBMC adhesion
Kang et al., Shock 1996 : Pretreatment with TGF-beta 1 for 24 h greatly augmented LPS induction of ICAM-1 and VCAM-1 expression, but decreased E-selectin expression
Hayashi et al., Infect Immun 1996 : The serum dependent ICAM-1 induction by LPS was observed in HGF ... Depletion of sCD14 from human serum markedly reduced ICAM-1 expression on HGF in response to LPS ... These results show that induction of ICAM-1 in HGF by LPS does not involve binding to cell surface CD14 but is mediated by serum derived sCD14
Keicho et al., Am J Respir Cell Mol Biol 1997 : This LPS mediated ICAM-1 induction was serum dependent but the LPS receptor, CD14, was not detected on the surface of the E1A transfectants
Li et al., Cell Immunol 1997 : Stimulation of IEC-4.1 cells with LPS or TNF-alpha markedly increased the surface expression of both ICAM-1 and VCAM-1, which correlated with the increased binding of macrophages to the stimulated IEC-4.1 cells
Fujisawa et al., J Dermatol Sci 1997 (Carcinoma, Squamous Cell) : This evidence contrasts with previously reported findings indicating that, in human cultured keratinocytes, ICAM-1 expression is induced by IFN-gamma and TNF-alpha, and not by either IL-1 or LPS
Heinzelmann et al., Cell Immunol 1997 : On monocytes, both LPS and MDP increased the expression of human leukocyte antigen ( HLA ) -DR ( maximal at 6 hr ), CD18 ( maximal at 1-3 hr ), and ICAM-1 ( maximal at 18-24 hr for LPS and 12 hr for MDP ) without increasing the production of superoxide ... On lymphocytes, only LPS increased ICAM-1 ( after 18 hr ) without affecting CD18, and a differential analysis demonstrated a generalized ICAM-1 upregulation in lymphocyte subsets after 18 hr : the most pronounced effect was measured in natural killer cells, followed by CD8 ( + ) T cells, B cells, and CD4 ( + ) T cells
Ishizaka et al., Nihon Kyobu Shikkan Gakkai Zasshi 1996 (Acute Disease...) : The LPS induced increases in ICAM-1 and ELAM-1 expression were dose-dependently suppressed by B464
Jones et al., Arch Surg 1997 (Dermatitis) : We have previously shown that the thiol oxidizing agent diethyl maleate prevents lipopolysaccharide (LPS) induced up-regulation of endothelial cell intercellular adhesion molecule-1 ( ICAM-1 ) in vitro
Ou et al., Nitric Oxide 1997 (Endotoxemia...) : In rats receiving NAME, LPS induced greater neutrophil infiltration and ICAM-1 expression than in the LPS + saline group, whereas NIL infusion did not
Lo et al., J Immunol 1998 : FACS analysis reveals that LPG treatment blocked the LPS mediated expression of E-selectin, intercellular adhesion molecule-1 , and vascular cell adhesion molecule-1 on endothelial cells and monocyte adhesion without altering the integrity of the endothelial monolayer ... FACS analysis reveals that LPG treatment blocked the LPS mediated expression of E-selectin, intercellular adhesion molecule-1 , and vascular cell adhesion molecule-1 on endothelial cells and monocyte adhesion without altering the integrity of the endothelial monolayer
Yu et al., Rheumatol Int 1998 (Arthritis, Rheumatoid) : Lipopolysaccharides (LPS) at low concentrations and sCD14 increased the ICAM-1 expression on RA synovial fibroblasts
Lee et al., J Korean Med Sci 1998 : TNF-alpha and LPS also induced MCP-1 and ICAM-1 gene expression
Yokoo et al., Hum Gene Ther 1998 (Glomerulonephritis) : On the assumption that the LPS induced ICAM-1 expression may regulate the site and timing of the delivery of vehicle cells into the glomerulus, vehicle cells were transduced with human glucocerebrosidase ( GC ) gene, using an adenovirus vector, and reintroduced into the mice
Mori et al., Gut 1999 : DEX also blunted the LPS induced increase in ICAM-1 expression in the caecum and distal colon