Gene interactions and pathways from curated databases and text-mining

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HMGB1 — IRF1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Dhupar et al., Shock 2011 (Reperfusion Injury) : Interferon regulatory factor 1 mediates acetylation and release of high mobility group box 1 from hepatocytes during murine liver ischemia-reperfusion injury ... Our study demonstrates that IRF-1 contributes to hepatocellular release of HMGB1 and further that IRF-1 is a necessary component of HMGB1 release in response to hypoxia or after liver I/R ... Using IRF-1 chimeric mice, we show that IRF-1 upregulation in hepatic parenchymal cells, and not in the bone marrow derived immune cells, is responsible for HMGB1 release during ischemic liver injury ... Finally, our study also demonstrates a role for IRF-1 in modulating the acetylation status and subsequent release of HMGB1 through histone acetyltransferases ... We found that serum HMGB1 is acetylated after liver I/R and that this process was dependent on IRF-1
Pan et al., Chin Med J (Engl) 2013 : Interferon regulatory factor-1 mediates the release of high mobility group box-1 in endotoxemia in mice