Nakanaga et al., Am J Physiol Lung Cell Mol Physiol 2007
(Carcinoma, Squamous Cell...) :
Last, we show that dual oxidase 1 (Duox1) , a homolog of NADPH oxidase in airways, mediates TACE activation and IL-8 expression via generation of reactive oxygen species
Boots et al., J Biol Chem 2009
:
Following previous reports showing that DUOX1 is activated by extracellular ATP and purinergic receptor stimulation, this study demonstrates that airway epithelial IL-8 production in response to several bacterial stimuli involves ATP release and DUOX1 activation