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ITGB1 — TLN2

Pathways - manually collected, often from reviews:

• KEGG Focal adhesion: TLN1/TLN2 → Complex of 21 proteins (protein-protein, binding/association)

Text-mined interactions from Literome

Calderwood et al., Biochem Soc Trans 2004 : Formation of this talin-integrin complex plays a critical role in integrin activation, since mutations, in either talin or integrin beta tails, which disrupt complex formation, inhibit integrin activation
Ithychanda et al., J Biol Chem 2009 : Binding of the actin linking protein, talin, to integrin beta cytoplasmic tails ( CTs ) induces high affinity ligand binding ( integrin activation ), whereas binding of another actin linking protein, filamin, to the integrin beta CTs negatively regulates this process by blocking the talin-integrin interaction