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CD44 — EGF

Text-mined interactions from Literome

Monaghan et al., J Pathol 2000 (Astrocytoma...) : No EGF induced increase in CD44s was observed after treatment of cells with the wild-type EGFR tyrosine kinase inhibitor Tyrphostin AG1478 ( 30 nM ) ... Up-regulation of CD44 by EGF is also prevented by the transcriptional inhibitor actinomycin D ( 5 microg/ml ) and by blocking the MAP kinase ( MAPK ) pathway using the MEK inibitor U0126 ( 100 microM ) ... These results suggest that increased CD44 expression in response to EGF stimulation plays a significant role in astrocytoma invasion
Ellis et al., Exp Cell Res 2007 : The cell activation and manifestation stages for each cytokine are mediated by distinct matrix dependent mechanisms : motogenetic activation by EGF requires the concomitant functionality of EGFR and the hyaluronan receptor CD44 , whereas activation by TGF-alpha requires EGFR and integrin alphavbeta3 ... In contrast, the mitogenic activities of EGF and TGF-alpha are independent of CD44 and alphavbeta3 functionality
Barnes et al., PloS one 2010 (Atrophy...) : Our results indicate that ( i ) RAL induced in vitro and in vivo keratinocyte proliferation is a CD44 dependent phenomenon and requires the presence of HA, HB-EGF , erbB1 and MMPs, ( ii ) RAL and HAFi show a synergy in vitro and in vivo in mouse skin, and ( iii ) the combination of RAL and HAFi seems to have an important therapeutic effect in dermatoporosis
Zhang et al., Clin Exp Metastasis 1996 : We investigated whether EGF regulates cellular interactions with ECM components, and in particular, hyaluronate, by modulating CD44 expression
Zhang et al., J Biol Chem 1997 : In this investigation, transcriptional regulation of CD44 by EGF was confirmed by defining an EGF-regulatory element ... Our studies indicate that EGF induces CD44 gene expression through an interaction between a specific ERE and putative novel transcriptional factor so as to regulate cell attachment to extracellular matrix