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EGF — TRPM6

Text-mined interactions from Literome

Thebault et al., J Am Soc Nephrol 2009 : EGF increases TRPM6 activity and surface expression ... Recent identification of a mutation in the EGF gene that causes isolated recessive hypomagnesemia led to the finding that EGF increases the activity of the epithelial magnesium ( Mg2+ ) channel transient receptor potential M6 (TRPM6) ... Stimulation of the EGF receptor increased current through TRPM6 but not TRPM7 ... In summary, EGF mediated stimulation of TRPM6 occurs via signaling through Src kinases and Rac1, thereby redistributing endomembrane TRPM6 to the plasma membrane
Wolf et al., Cancer Treat Rev 2009 (Neoplasms) : The latter was shown to cause hypomagnesaemia by impeding EGF dependent activation of TRPM6 , the main cation channel responsible for Mg transcellular absorption in the intestine and kidney
Ikari et al., Biochim Biophys Acta 2011 : Rapamycin and LY-294002, an inhibitor of phosphatidilinositol-3 kinase (PI3K) located upstream of mTOR, inhibited epidermal growth factor (EGF) induced expression of the TRPM6 protein without affecting TRPM7 expression in rat renal NRK-52E epithelial cells ... U0126, a MEK inhibitor, inhibited EGF induced increases in c-Fos, p-ERK, and TRPM6 levels