◀ Back to RELA

RELA — RNF19A

Text-mined interactions from Literome

Awane et al., J Immunol 1999 : In addition to activation of the NF-kappa B , IL-17 regulated the activities of extracellular regulated kinase, c-Jun N-terminal kinase, and p38 mitogen activated protein kinases in IEC-6 cells
Alpert et al., J Biol Chem 1999 : Thus, sustained p38 activation by various stimuli inhibits TNF induced IkappaB phosphorylation and NF-kappaB activation
Ivanov et al., Oncogene 2000 (Melanoma) : Forced expression of a dominant negative form of p38 ( p38-ASP ) or treatment with p38 pharmacological inhibitor, SB203580, increases NF-kappaB activity, Fas expression and the levels of UVC induced apoptosis in late stage melanoma cells
Carter et al., J Biol Chem 2000 : We found that the MEK -- > ERK pathway negatively regulates NF-kappaB-driven transcription, in part, by inhibiting p38 MAP kinase activity
Valladares et al., Endocrinology 2000 : However, TNFalpha induced NF-kappaB DNA binding activity is independent of p38MAPK and ERK activation
Bradbury et al., Cancer Res 2001 : In addition, the transient genetic activation of p38 ( MAPK ) inhibited IR induction of NF-kappaB gene expression in the absence of indomethacin
Li et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : Recent studies indicate that maximal IL-8 protein expression requires activation of NF-kappaB as well as activation of the MAP kinases ERK, JNK, and p38
Yang et al., Am J Respir Crit Care Med 2003 (Respiratory Distress Syndrome, Adult) : We found that nuclear translocation of NF-kappaB in this setting was dependent on the activation of p38 and Akt kinases
Lüschen et al., Exp Cell Res 2004 : Inhibition of p38 mitogen activated protein kinase reduces TNF induced activation of NF-kappaB , elicits caspase activity, and enhances cytotoxicity
Zhao et al., J Neuroimmunol 2004 (MAP Kinase Signaling System) : 15d-PGJ2 inhibited transactivation of NF-kappaB dependent promoters, as well as p38 and JNK MAPK phosphorylation induced by IL-1, while having no inhibitory effect on IFN induced Stat signaling pathways
Afaq et al., Int J Cancer 2005 (Edema...) : We also found that topical application of PFE resulted in inhibition of TPA induced phosphorylation of ERK1/2, p38 and JNK1/2, as well as activation of NF-kappaB and IKKalpha and phosphorylation and degradation of IkappaBalpha
Campbell et al., J Immunol 2004 (Arthritis, Rheumatoid) : This is mediated through p38 MAPK regulation of NF-kappaB
Eom et al., Oncogene 2005 : Furthermore, HD doxorubicin induced apoptosis but not LD doxorubicin induced mitotic catastrophe led to transient activation of NF-kappaB and strong, sustained activations of p38 , c-Jun N-terminal kinase, and caspases
Selvaraj et al., J Leukoc Biol 2005 (MAP Kinase Signaling System...) : Selective inhibitors of the extracellular signal regulated kinase ( ERK ) 1/2 pathway and p38 mitogen activated protein kinase ( MAPK ), but not Jun N-terminal kinase, significantly reduced the activation of NF-kappaB and the production of cytokines and chemokines induced by OmpA- E. coli, indicating a role for these kinases in the NF-kappaB/cytokine pathway
Jang et al., Free Radic Biol Med 2005 (MAP Kinase Signaling System) : Pharmacologic inhibition of extracellular signal regulated kinase ( ERK ) and p38 mitogen activated protein kinase ( p38 MAPK ) and dominant negative mutation of both enzymes suppressed not only Abeta induced NF-kappaB transactivation but also COX-2 expression and PGE ( 2 ) production
Murakami et al., Biol Chem 2006 (Inflammation...) : ACA abrogated ERK1/2 and JNK1/2, but not p38 activation, as well as the activation and transcriptional activation of NF-kappaB and CREB, whereas nobiletin allowed phosphorylation of these MAPKs, while it suppressed AP-1, NF-kappaB, and CREB activation
Kefaloyianni et al., Cell Signal 2006 (MAP Kinase Signaling System) : ERK1/2 and p38-MAPK signalling pathways, through MSK1, are involved in NF-kappaB transactivation during oxidative stress in skeletal myoblasts
Olson et al., Infect Immun 2007 : p38 mitogen activated protein kinase controls NF-kappaB transcriptional activation and tumor necrosis factor alpha production through RelA phosphorylation mediated by mitogen- and stress activated protein kinase 1 in response to Borrelia burgdorferi antigens
Guo et al., Peptides 2006 (MAP Kinase Signaling System) : These results also demonstrate that Ang II leads to MAPK phosphorylation and p38MAPK pathway induced NF-kappaB activation
Kobori et al., Br J Pharmacol 2007 (Adenocarcinoma...) : Ergosterol peroxide and ergosterol suppressed LPS induced DNA binding activity of NF-kappaB and C/EBPbeta, and inhibited the phosphorylation of p38 , JNK and ERK MAPKs
Tirumurugaan et al., Am J Physiol Lung Cell Mol Physiol 2007 (MAP Kinase Signaling System) : EMSAs confirmed the role of p38 and JNK in mediating NF-kappaB and AP-1 activation
Saha et al., J Immunol 2007 (Inflammation) : Several studies have shown that blocking p38 activity attenuates the transcriptional activity of the proinflammatory transcription factor NF-kappaB without altering its DNA binding activity ... In this study, we delineate that p38 controls the transcriptional activity of NF-kappaB by regulating acetylation of p65, but not its phosphorylation
Piao et al., J Biol Chem 2008 : Mutagenesis of Tyr-86, Tyr-106, and Tyr-159 residues within the Toll-IL-1 receptor domain impaired Mal tyrosine phosphorylation, interactions with Bruton tyrosine kinase, phosphorylation of p38 , and NF-kappaB activation
Liu et al., Eur J Pharmacol 2008 (Disease Models, Animal...) : These data suggest that p38MAPK signaling may be involved in the activation of NF-kappaB , and activation of p38MAPK signaling may be one of the mechanisms of acute lung injury
Hisatsune et al., J Immunol 2008 : Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation
Wang et al., J Biol Chem 2009 (Carcinoma, Hepatocellular) : Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor related apoptosis inducing ligand ( TRAIL ) -induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB ... In the presence of melittin, TRAIL induced apoptosis is significantly increased in TRAIL-resistant HCC cells, which may be attributed to melittin induced TAK1-JNK/p38 activation and melittin mediated inhibition of IkappaBalpha kinase-NFkappaB
Zhang et al., Curr Eye Res 2008 (Endophthalmitis) : A significant inhibitory effect of besifloxacin was observed at 1 or 10 microg/ml. Besifloxacin inhibited IkappaB degradation, NFkappaB nuclear translocation, and activation of p38 and JNK MAPKs
Jacks et al., J Biol Chem 2010 : Here we report that the CK2 protein kinase, which contributes to NF-kappaB activation following UV radiation in a p38 dependent manner, physically interacts with MSK2 but not MSK1 and that CK2 inhibition specifically impairs UV-induced MSK2 kinase activation
Chen et al., Exp Eye Res 2010 (Dry Eye Syndromes) : p38 inhibitor suppressed hyperosmoticity induced NF-kappaB activation, indicating that NF-kappaB activation was dependent on p38 activation
Martins et al., PloS one 2010 (Salmonella Infections) : This anti-inflammatory effect was correlated with an inhibitory effect of Sb on ST-induced activation of the MAPKs ERK1/2, p38 and JNK as well as on activation of NF-kappaB
Yang et al., Atherosclerosis 2010 : N-acetylcysteine, SP600125 ( JNK inhibitor ) and SB203580 ( p38 MAPK inhibitor ) attenuated TNF-alpha induced DNA binding activities of both AP-1 and NF-kappaB
Yoon et al., Infect Immun 2010 : Inhibition of p38 mitogen activated protein kinase ( MAPK ) using SB203580 and small interfering RNA ( siRNA ) transfection resulted in a significant reduction in BFT induced I kappaB kinase (IKK)/NF-kappaB activation and hBD-2 expression
Twait et al., Pancreatology 2010 (Pancreatitis) : Dominant negative p38 mitogen activated protein kinase expression inhibits NF-kappaB activation in AR42J cells
Shapiro et al., Proc Natl Acad Sci U S A 1998 : These results demonstrate induction of HIV-1 by IL-18 in a monocyte target associated with an intermediate role for TNF and IL-6, activation of p38 mitogen activated protein kinase, and nuclear translocation of NF-kappaB