Gene interactions and pathways from curated databases and text-mining

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AKT1 — EEF1A2

Text-mined interactions from Literome

Brouet et al., Circ Res 2001 : Finally, we showed that statin promoted the tyrosine phosphorylation of hsp90 and the direct interaction of hsp90 with Akt , which further potentiated the NO-dependent angiogenic processes
Skaletz-Rorowski et al., Cardiovasc Res 2003 (Translocation, Genetic) : Treatment with phosphoinositide 3-kinase ( PI 3-kinase ) inhibitors or the HMG-CoA reductase reaction product L-mevalonate blocks the translocation of Akt in response to statin stimulation ... These results suggest that statin activation of Akt signaling is mediated by the translocation of Akt to cholesterol-sensitive membrane structures within activated ECs
Cosentino et al., Recenti Prog Med 2003 (Acute Disease...) : Recent findings on statin induced inhibition of Rho/Rho-kinase and activation of Akt provide new insights into the protective action of statins in acute coronary syndromes
Bussolati et al., J Am Soc Nephrol 2005 : The statin induced Akt activation may protect from the loss of nephrin by an inhibition of its redistribution and shedding and by a stimulation of its synthesis
Roudier et al., Mol Cancer Ther 2006 (Carcinoma, Hepatocellular...) : Taken together, these data suggest that a mTOR dependent , statin induced inhibition of Akt phosphorylation and nuclear translocation sensitizes cells to cytostatic drugs
Amiri et al., Oncogene 2007 (Breast Neoplasms...) : eEF1A2 activates Akt and stimulates Akt dependent actin remodeling, invasion and migration ... Furthermore, eEF1A2 expression is sufficient to activate Akt in a PI3K dependent fashion and inactivation of eEF1A2 by short interfering RNA reduces Akt activity
Merla et al., Am J Physiol Heart Circ Physiol 2007 : The central role of adenosine in statin induced ERK1/2, Akt , and eNOS phosphorylation