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IL18 — MMP16
Text-mined interactions from Literome
Meisser et al., Mol Hum Reprod 1999
:
The aim of this study was to determine the
effects of tumour necrosis factor alpha (TNF),
interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of
matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Abraham et al., Int Immunol 2002
:
The present study examined differential
effects of pro-inflammatory
[IL-18 , IL-12 and tumor necrosis factor (TNF)-alpha ] versus anti-inflammatory ( IL-4 ) cytokines on the modulation of
MMP and their endogenous tissue inhibitors ( TIMP ) expression in the U937 cell line
Sun et al., Connect Tissue Res 2003
(Arthritis, Rheumatoid) :
Furthermore, the
induction of the
MMP expression and activities by
interleukin-1 was suppressed by the oscillatory shear
Dai et al., Ann Rheum Dis 2005
(Arthritis...) :
In chondrocytes responding to IL18,
IL18 ( 1-100 ng/ml ) slightly
increased the production of MMP-1,
MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Chandrasekar et al., J Biol Chem 2006
(Atherosclerosis) :
Because we demonstrated previously that the proinflammatory and proatherogenic cytokine interleukin-18 (IL-18) stimulates SMC proliferation ( Chandrasekar, B., Mummidi, S., Valente, A. J., Patel, D. N., Bailey, S. R., Freeman, G. L., Hatano, M., Tokuhisa, T., and Jensen, L. E. ( 2005 ) J. Biol. Chem. 280, 26263-26277 ), we investigated whether
IL-18 induces SMC migration in an
MMP dependent manner and whether the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin can inhibit this response