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PAK1 — SRC

Pathways - manually collected, often from reviews:

• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → utrophin (UTRN) (modification, collaborate)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: Ach R/RAPSYN complex (CHRM1_CHRNA1-RAPSN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: utrophin (UTRN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin/Ach R/RAPSYN/utrophin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN-CHRM1_CHRNA1-RAPSN-UTRN) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) → None (modification, activates)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) → None (modification, activates)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → cortactin (CTTN) (modification, collaborate)
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin/cortactin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3-CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: cortactin (CTTN) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1) → Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  
• BioCarta agrin in postsynaptic differentiation: Laminin (LAMA1/LAMC3/LAMA2/LAMB1/LAMC1/LAMB2/LAMA4/LAMA5/LAMC2/LAMB3/LAMA3) → agrin/Integrin-alpha/Integrin-beta/dystroglycan 1/SRC/FAK/Paxillin/PKL/PIX/PAKs/dystrophin/actin/laminin complex (AGRN-ITGA1-ITGB1-DAG1-SRC-PTK2-PXN-GIT2-ARHGEF6_ARHGEF7-PAK3_PAK7_PAK1_PAK2_PAK6_PAK4-DMD-ACTA1-LAMA1_LAMC3_LAMA2_LAMB1_LAMC1_LAMB2_LAMA4_LAMA5_LAMC2_LAMB3_LAMA3) (modification, collaborate)
  
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn/Paxillin complex (PTK2-YES1_SRC_FYN-PXN) → PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1) (modification, collaborate)
  Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn/Paxillin complex (PTK2-YES1_SRC_FYN-PXN) → FAK/Src-Yes-Fyn/Paxillin/PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1-PTK2-YES1_SRC_FYN-PXN) (modification, collaborate)
  Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1) → FAK/Src-Yes-Fyn/Paxillin/PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1-PTK2-YES1_SRC_FYN-PXN) (modification, collaborate)
  Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Brown et al., Mol Biol Cell 2005, Schober et al., J Cell Biol 2007, Yu et al., Mol Biol Cell 2009
  Evidence: physical interaction
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN) → PAK1/betaPIX/PKL/NCK1-2 complex (PAK1-ARHGEF7-GIT2-NCK2_NCK1) (modification, activates)
  Turner et al., J Cell Biol 1999, Brown et al., Mol Biol Cell 2002, Yu et al., Mol Biol Cell 2009
  Evidence: mutant phenotype, assay
• Reactome Reaction: PAK1 → SRC (reaction) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
• Reactome Reaction: PAK1 → SRC (indirect_complex) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
• WikiPathways Rac1/Pak1/p38/MMP-2 pathway: SRC → PAK1 (unknown)

Text-mined interactions from Literome

Schmitz et al., Biochem Biophys Res Commun 2002 : In VSMC, PAK activation by LPA is mediated by Galpha ( i ) and is dependent on Src , whereas EGF- or PDGF receptor transactivation are not involved
Zhao et al., Journal of neuroinflammation 2011 (Wounds and Injuries) : Our results suggest that neuroimmune modulation following traumatic stress is mediated by a cascade that involves c-Src mediated enhancement of miRNA222 expression and downregulation of PAK1 , which in turn impairs signaling via IL-1ß/IL1-RI, leading to immunosuppression
Yan et al., Stroke 2013 (Subarachnoid Hemorrhage) : Downstream to PAR-1, c-Src dependent activation of p21 activated kinase-1 led to an increased serine/threonine phosphorylation of vascular endothelial-cadherin ; immunoprecipitation results revealed an enhanced binding of phosphorylated vascular endothelial-cadherin with endocytosis orchestrator ß-arrestin-2
Schmitz et al., Circ Res 1998 : Activation of both PAK and JNK was partially inhibited by tyrosine kinase inhibitors but not by specific Src inhibitors, suggesting regulation by a tyrosine kinase other than c-Src