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CYP7A1 — VDR

Pathways - manually collected, often from reviews:

• WikiPathways Drug Induction of Bile Acid Pathway: VDR → CYP7A1 (inhibition)

Text-mined interactions from Literome

Jiang et al., Biochem Biophys Res Commun 2006 (Carcinoma, Hepatocellular) : In co-transfection experiments in HepG2 cells, VDR repressed the activity of rat CYP7alpha promoter in a ligand dependent manner through inhibition of LXRalpha signaling
Han et al., Drug Metab Dispos 2009 : Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes ... 1alpha, 25-Dihydroxy-vitamin D ( 3 ) or LCA acetate activated VDR inhibited CYP7A1 mRNA expression and bile acid synthesis, whereas small interfering RNA to VDR completely abrogated VDR inhibition of CYP7A1 mRNA expression in HepG2 cells
Han et al., Mol Endocrinol 2010 : Inhibition of c-Src abrogated VDR ligand dependent inhibition of CYP7A1 mRNA expression