◀ Back to JAK2
IL3RA — JAK2
Pathways - manually collected, often from reviews:
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BioCarta il 3 signaling pathway:
IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
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BioCarta il 3 signaling pathway:
IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
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BioCarta il 3 signaling pathway:
IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3)
→
JAK2
(modification, collaborate)
-
BioCarta il 3 signaling pathway:
IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3)
→
IL-3/IL-3R-alpha/IL-3R-beta complex (IL3RA-IL3-CSF2RB)
(modification, collaborate)
-
BioCarta il 3 signaling pathway:
JAK2
→
IL-3/IL-3R-alpha/IL-3R-beta complex (IL3RA-IL3-CSF2RB)
(modification, collaborate)
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KEGG Jak-STAT signaling pathway:
CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR
→
JAK1/JAK2/JAK3/TYK2
(protein-protein, phosphorylation)
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NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
SHIP (INPP5D)
(modification, collaborate)
Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
SHIP (INPP5D)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
GRB2/GAB2 complex (GRB2-GAB2)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2)
(modification, collaborate)
Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
JAK2 (JAK2)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
(modification, collaborate)
Quelle et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database IL3-mediated signaling events:
JAK2 (JAK2)
→
IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA)
(modification, collaborate)
Quelle et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA)
(modification, collaborate)
Quelle et al., Mol Cell Biol 1994
Evidence: assay
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
GRB2/GAB2 complex (GRB2-GAB2)
(modification, collaborate)
Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
STAT5 (STAT5A/STAT5B)
(modification, activates)
Azam et al., EMBO J 1995, Chin et al., Blood 1996
Evidence: assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
STAT5-active (STAT5A/STAT5B)
(modification, activates)
Azam et al., EMBO J 1995, Chin et al., Blood 1996
Evidence: assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA)
→
SHP2 (PTPN11)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
SHP2 (PTPN11)
(modification, collaborate)
Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
PI3K complex (PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1)
(modification, collaborate)
Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
(modification, collaborate)
Bone et al., Cell Signal 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA)
→
SHC (SHC1)
(modification, collaborate)
Bone et al., Cell Signal 2000
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database IL3-mediated signaling events:
IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA)
→
SHC (SHC1)
(modification, collaborate)
Bone et al., Cell Signal 2000
Evidence: mutant phenotype, physical interaction
-
Reactome Reaction:
IL3RA
→
JAK2
(indirect_complex)
Orban et al., Blood 1999*, Kitamura et al., Cell 1991
-
Reactome Reaction:
IL3RA
→
JAK2
(reaction)
Orban et al., Blood 1999*, Sakamaki et al., EMBO J 1992, Duronio et al., J Biol Chem 1992, Kitamura et al., Cell 1991, Sorensen et al., J Biol Chem 1989, Quelle et al., Mol Cell Biol 1994, Feng et al., Mol Cell Biol 1997, Bone et al., J Biol Chem 1997, Flores-Morales et al., Mol Cell Endocrinol 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Pradhan et al., J Biol Chem 2010
:
In addition, expression of components of the interleukin-3 receptor,
IL3Ra and the common beta chain,
activated JAK2-V617F as well as STAT5 and ERK
Morella et al., Blood 1995
(Carcinoma, Hepatocellular...) :
Because
IL-3R was less
dependent on
JAK2 than c-mpI, different levels of JAK2 expression may account, in part, for the quantitative difference in IL-3 and TPO response among various cell lines