Gene interactions and pathways from curated databases and text-mining

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EGF — MET

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MET → EGF (decreases) Olsen et al., Cell 2006*
    Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database
  • KEGG Focal adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC → EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB (protein-protein, activation)
  • KEGG Melanoma: EGF/FGF1/FGF10/FGF11/FGF12/FGF13/FGF14/FGF16/FGF17/FGF18/FGF19/FGF2/FGF20/FGF21/FGF22/FGF23/FGF3/FGF4/FGF5/FGF6/FGF7/FGF8/FGF9/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD → EGFR/FGFR1/IGF1R/MET/PDGFRA/PDGFRB (protein-protein, activation)
  • WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: EFNA1/FGF1/FGF11/FGF10/EFNA2/EGF/FGF12/CSF1/ANGPT4/ANGPT2/ANGPT1/VEGFA/EFNA3/EFNA4/EFNA5/FGF14/FGF19/FGF17/FGF18/FGF2/FGF3/FGF4/FGF6/FGF7/FGF8/FGF9/FIGF/HGF/IGF1/INS/INS/KITLG/VEGFC/VEGFB/PDGFB/PGF/PDGFA/NGF/PDGFC/FGF21/FGF22/PDGFD/FGF20/FGF16 → FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK (activation)
  • WikiPathways Focal Adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC → BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 (activation)

Text-mined interactions from Literome

Takeuchi et al., J Biol Chem 2004 : Cell-surface biotin labeling analysis showed that the HGF/SF receptor remained on the cell surface until at least 30 min after HGF/SF addition but that the EGF receptor level on the cell surface was attenuated at an earlier time after EGF addition
Rice et al., Oncol Res 2009 (Carcinoma, Non-Small-Cell Lung...) : SNX-2112 reduced EGF cross-talk and activation of the c-Met receptor by causing c-Met degradation
Brusevold et al., J Oral Pathol Med 2012 (Carcinoma, Squamous Cell...) : In the E10 cell line, EGF and HGF induced phosphorylation of EGF receptor (EGFR) and Met , respectively, phosphorylation of ERK1/2, p38 and Akt, and dose dependent activation of cell migration
Takeuchi et al., Exp Cell Res 1996 (Carcinoma...) : Therefore, we compared the effect of EGF on HGF stimulated HGF receptor phosphorylation in these cell lines ... In MKN7 cells, the increased phosphorylation was further enhanced by EGF, although EGF alone did not affect tyrosine phosphorylation of the HGF receptor