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CDC73 — NOS3

Text-mined interactions from Literome

Qu et al., Crit Care Med 1999 (Necrosis...) : We found that : a ) cNOS is the predominant NOS in the intestine and its activity is inversely correlated to the level of tissue injury ; b ) there is a time dependent increase in cNOS activity in sham operated animals, which was abolished by PAF ; c ) Western blotting and immunohistochemistry showed iNOS present in the normal intestine, localizing mainly in crypt cells ; d ) iNOS inhibitors attenuated PAF induced injury in animals with high cNOS activity, but had no protective effect in animals with low cNOS activity ; e ) 3-morpholinosydnonimine, alone or together with S-methylisothiourea, alleviated PAF induced injury ; and f ) neutrophil depletion blocked the suppressive effect of PAF on cNOS and prevented injury
Loucks et al., Can J Cardiol 2003 (Myocardial Reperfusion Injury) : PAF may play a role in the regulation of endothelial NOS mRNA expression and contribute to apoptosis during ischemia-reperfusion in the heart
Sánchez et al., Am J Physiol Heart Circ Physiol 2006 : ACh and platelet activating factor (PAF) lead to endothelial NO synthase (eNOS) phosphorylation and NO release ... We suggest that PAF induced eNOS translocation preferentially to cytosol reflects a differential signaling mechanism related to changes in permeability, whereas ACh induced eNOS translocation to the TGN is related to vasodilation
Sánchez et al., Proc Natl Acad Sci U S A 2009 : PAF induced Ser-1177-eNOS phosphorylation in ECV-CD8eNOSGFP and CVEC transfected with dyn2K44A, but it dephosphorylated eNOS at Ser-1177 in CVEC transfected with cav1Y14F
Yang et al., Eur Respir J 2010 (Pulmonary Edema) : Pharmacological inhibition of the ASM pathway with imipramine, D609 or dexamethasone blocked the PAF induced increase of caveolin-1 and eNOS in caveolae, and the decrease in eNO production and oedema formation
Costa et al., Stem cell research 2013 : We have demonstrated a hitherto unrecognized role for LPA and PAF in the regulation of eNOS subcellular localization
De Kimpe et al., Br J Pharmacol 1995 (Acute Kidney Injury...) : 6. Thus, the intracellular release of PAF contributes to the circulatory and renal failure and induction of nitric oxide synthase elicited by LTA in anaesthetized rats