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CA2 — PLA2G4A

Text-mined interactions from Literome

Pedersen et al., Eur J Biochem 2000 (Carcinoma, Ehrlich Tumor) : Stimulation by either hypotonic cell swelling or addition of the Ca2+ ionophore A23187 results in translocation of cPLA2alpha , but not cPLA2gamma, to the nucleus, where it forms hot-spot-like clusters
Kitatani et al., Arch Biochem Biophys 2000 : The effect of ceramide on Ca2+ dependent translocation of cytosolic phospholipase A2 (cPLA2) to membranes was studied ... Sphingomyelinase and C6-ceramide, but not C6-dihydroceramide, a control analog of C6-ceramide, also facilitated the Ca2+ dependent increase in the cPLA2 protein, as well as the activity, in membranes induced by addition of Ca2+ into platelet lysate ... These findings suggest that ceramide in membranes potentiates Ca2+ dependent cPLA2 translocation from cytosol to membranes, probably through modification of membrane phospholipid organization
Kifor et al., American journal of physiology. Renal physiology 2001 (MAP Kinase Signaling System) : High Ca2+o increased serine phosphorylation of the 85-kDa cytosolic phospholipase A2 (cPLA2) in both parathyroid and HEKCaR cells
Siegel et al., J Biol Chem 2001 (Calcium Signaling...) : In the present study we have investigated the role of cytosolic phospholipase A2 (cPLA2) and AA in acetylcholine (ACh)- and bombesin induced Ca2+ signaling
Fatima et al., J Pharmacol Exp Ther 2001 : SB203580 induced cPLA2 phosphorylation was inhibited by depletion of Ca2+ from the medium, by the voltage operated Ca2+ channel blocker nifedipine, and by the calmodulin inhibitor W-7
Murakami et al., J Biochem 2002 : Intracellular activation of cPLA2alpha is tightly regulated by Ca2+ and phosphorylation
Kim et al., Prostaglandins Leukot Essent Fatty Acids 2001 : The epidermal cPLA2 is Ca2+ dependent , active at micromolar concentration of Ca2+ and resistant to disulfide reducing agents
Kudo et al., Prostaglandins Other Lipid Mediat 2002 (Arteriosclerosis...) : The activation of cPLA2alpha is tightly regulated by Ca2+ and phosphorylation
Hirabayashi et al., Biol Pharm Bull 2004 : Ca2+ binding induces translocation of cPLA2alpha from the cytosol to the perinuclear membranes
Gentili et al., J Cell Biochem 2004 : Intracellular Ca2+ chelation ( BAPTA-AM, 5 microM ) suppressed the serine phosphorylation of cPLA2 in both, young and aged rats, demonstrating that intracellular Ca2+ is required for full activation of cPLA2 in enterocytes stimulated with PTH
Luo et al., Cell Signal 2006 (MAP Kinase Signaling System) : LPS induced expression of cPLA2 and release of PGE2 was attenuated by inhibitors of tyrosine kinase ( genistein ), phosphatidylcholine-phospholipase C ( D609 ), phosphatidylinositol-phospholipase C ( U73122 ), PKC ( GF109203X and staurosporine ), removal of Ca2+ by BAPTA/AM plus EDTA, MEK1/2 ( PD98059 ), p38 ( SB202190 ), JNK ( SP600125 ), and phosphatidylinositol 3-kinase ( PI3-K ; LY294002 and wortmannin )
Nakamura et al., Biochem Pharmacol 2006 : C1P increased the enzymatic activity of cPLA2alpha over two-fold in the presence of Ca2+
Olsson et al., Journal of inflammation (London, England) 2006 : Cytosolic phospholipase A2 is a major down-stream target and this enzyme is regulated by both phosphorylation and an increase in intracellular Ca2+
Liu et al., FEBS Lett 2006 (Calcium Signaling) : We conclude that in A7r5 cells vasopressin stimulates AA release via a Ca2+ dependent activation of cPLA2
Taniguchi et al., Biochem Pharmacol 2007 : Our data show that Na3VO4 stimulates AA release largely via cPLA2alpha activation in Ca2+ dependent manner, and the cross-talk between Src and PKC and the ERK dependent pathways are involved in Na3VO4 induced AA release from L929 cells
St-Onge et al., Biochim Biophys Acta 2007 : We found that the Ca2+ dependent type IV cytosolic phospholipase A2 (cPLA2) was pivotally involved in the COX-2 mediated generation of PGE2 in response to a calcium ionophore, as determined by the use of selected PLA2 inhibitors
Persaud et al., Arch Physiol Biochem 2007 : Arachidonic acid ( AA ) is generated in pancreatic beta-cells through the activation of Ca2+ dependent cytosolic phospholipase A2 (cPLA2) and the consequent hydrolysis of membrane phospholipids in the sn-2 position of the glycerophospholipid backbone
Murray-Whelan et al., Eur J Biochem 1995 : We addressed the possibility that the activation of cPLA2 by Ca2+ and/or protein kinase C is dependent on G alpha i2 ... specifically inhibits Ca2+ activation of cPLA2
Nalefski et al., J Biol Chem 1994 : Cytosolic phospholipase A2 (cPLA2) associates with natural membranes in response to physiological increases in Ca2+ , resulting in the selective hydrolysis of arachidonyl phospholipids
Kramer et al., J Biol Chem 1993 : We conclude that 1 ) cPLA2 is likely to play an important role in agonist induced mobilization of arachidonic acid and 2 ) thrombin elicits rapid and full activation of cPLA2 not only by promoting a rise in cytosolic free Ca2+ but also by inducing phosphorylation of cPLA2 thereby improving its catalytic activity
Reynolds et al., Biochim Biophys Acta 1993 : Using a pure recombinant enzyme, we have confirmed that cPLA2 is not absolutely dependent on Ca2+ , since Sr2+, Ba2+ and Mn2+ also gave full enzyme activity
Clark et al., J Lipid Mediat Cell Signal 1995 : Therefore, full activation of cPLA2 requires both increased cytosolic Ca2+ and cPLA2 phosphorylation at Ser-505
Muthalif et al., J Biol Chem 1996 : Activation of adrenergic receptors with NE in VSMC caused translocation of CaM kinase II, MAP kinase, and cPLA2 to the nuclear envelope only in the presence of extracellular Ca2+
Berguerand et al., Am J Respir Cell Mol Biol 1997 (Cystic Fibrosis) : As the binding of cPLA2 to membranes is Ca2+ dependent , the increased coupling to PLC could cause the hypersensitivity to bradykinin
Crawford et al., Mol Biol Cell 1998 : Although translocation of cPLA2 from cytosol to membrane was Ca2+ dependent , phosphorylation of cPLA2 was attachment dependent and could occur both on the membrane and in the cytosol
Zhang et al., Eur J Pharmacol 1999 : In the present study, we investigated the involvement of Ca2+ signaling and protein kinases in the effect of Ca2+-ATPase inhibitors on the activation of cytosolic phospholipase A2 (cPLA2) in human polymorphonuclear neutrophils
Hirabayashi et al., J Biol Chem 1999 (Calcium Signaling) : A Ca2+ regulated cytosolic phospholipase A2 (cPLA2) plays a dominant role in the release of AA