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EPHB2 — MAP2K4

Text-mined interactions from Literome

Meerzaman et al., Am J Physiol Lung Cell Mol Physiol 2001 : The activation of ERK2 was completely blocked either by a dominant negative Ras mutant or in the presence of a mitogen activated protein kinase kinase ( MEK ) inhibitor
Bobrovskaya et al., J Neurochem 2001 (MAP Kinase Signaling System) : The inhibitors of mitogen activated protein kinase kinase 1/2 ( MEK1/2 ) activation, PD98059 ( 0.1-50 microM ) and UO126 ( 0.1-10 microM ), dose-dependently inhibited both ERK2 and Ser31 phosphorylation on TOH in response to AII, suggesting MEK1/2 involvement
Wang et al., J Hepatol 2002 (MAP Kinase Signaling System) : PD 98059, a mitogen activated protein kinase kinase inhibitor, and glutathione, an anti-thiol-oxidant, not only blocked Cpd 5-induced ERK phosphorylation, but also antagonized the activation of CPP-32, the altered Bcl-2/Bax expression, and DNA fragmentation
Utsugi et al., Eur J Pharmacol 2002 : Furthermore, mitogen activated protein kinase kinase ( MEK)-1-specific inhibitor, 2- ( 2-amino-3-methoxyphenyl ) -4H-1-benzopyran-4-one ( PD 98059 ), blocked the lipopolysaccharide induced p44/42 ERK activation and PDGF production
Suthiphongchai et al., Oncol Res 2003 (Adenocarcinoma...) : Inhibition of mitogen activated protein kinase kinase 1 ( MEK1 ), an upstream regulator of ERK1/2 , with PD98059 resulted in a dose dependent reduction of invasiveness with different IC50 values in the three Dunning cell lines
Fanning et al., J Biol Chem 2003 (MAP Kinase Signaling System...) : Mechanical compression induced a phased phosphorylation of ERK consisting of a rapid induction of ERK1/2 phosphorylation at 10 min, a rapid decay, and a sustained level of ERK2 phosphorylation that persisted for at least 24 h. Mechanical compression also induced the phosphorylation of p38 MAPK in strictly a transient fashion, with maximal phosphorylation occurring at 10 min. Mechanical compression stimulated SEK1 phosphorylation, with a maximum at the relatively delayed time point of 1 h and with a higher amplitude than ERK1/2 and p38 MAPK phosphorylation
Ohnishi et al., J Biol Chem 2004 : However, PD98059, a specific inhibitor of mitogen activated protein kinase kinase ( MEK1 ), inhibited ERK activation by TGF-beta(1), and consequently attenuated TGF-beta(1) enhancement of its own mRNA expression in PSCs
Song et al., J Leukoc Biol 2004 : Constitutively active mitogen activated protein kinase kinase ( MEK ) induced MIP-1alpha, and Ras dominant negative ( DN ) inhibited IC-induced ERK phosphorylation and MIP-1alpha production
Kim et al., J Lipid Res 2005 : Pretreatment of HDFs with EPA inhibited UV-induced MMP-1 expression in a dose dependent manner and also inhibited the UV-induced activation of ERK and JNK by inhibiting ERK kinase ( MEK1 ) and SAPK/ERK kinase 1 (SEK1) activation, respectively
Moon et al., FEBS Lett 2006 : Pretreatment of HSFs with 2',4',7-THF inhibited UV-induced MMP-1 expression in a dose dependent manner, and also inhibited the UV-induced activations of ERK and JNK by inhibiting MEK1 and SEK1 activation, respectively
Raines et al., Biochem J 2006 : Ca2+ mediated ERK1/2 activation in NO* producing cells could be restored by exogenous expression of constitutively active mitogen activated protein kinase kinase 1
Kam et al., Cell Signal 2007 (Astrocytoma...) : Consistently, overexpression of MEK1 and constitutively active JNKK in U87 cells led to ERK and JNK activation, respectively, which was accompanied with markedly increased GFAP production
Chen et al., J Neurochem 2008 : Although mitogen activated protein kinase kinase ( MEK ) and extracellular signal regulated protein kinase ( ERK ) are activated by GW5074, pharmacological inhibition of MEK-ERK signaling by U0126 or PD98059 does not reduce neuroprotection suggesting that B-Raf signals through a non-canonical signaling pathway
Ko et al., Carcinogenesis 2008 (Carcinoma, Non-Small-Cell Lung...) : Enhancement of ERK1/2 signaling by constitutively active mitogen activated protein kinase kinase 1/2 ( MKK1/2-CA ) increased Rad51 protein levels and protein stability in gefitinib and cisplatin or MMC cotreated cells
Lorenz et al., Nat Med 2009 (Cardiomegaly...) : ERK1/2 is activated by mitogen activated protein kinase kinase-1 ( MEK1 ) and MEK2 ( commonly referred to as MEK1/2 ) -dependent phosphorylation in the TEY motif of the activation loop, but how ERK1/2 is targeted toward specific substrates is not well understood
Huang et al., Carcinogenesis 2009 (Glioma) : U-0126, the mitogen activated protein kinase kinase ( MAPK kinase ) inhibitors blocked ERK activation and cell proliferation induced by diazoxide
Petecchia et al., Chest 2009 (MAP Kinase Signaling System) : The involvement of epidermal growth factor receptor (EGFR)-extracellular signal regulated kinase ( ERK ) 1/2 cascade in CSC induced damage was shown by the observation that exposure to CSC ( 5 % ) induced a marked phosphorylation of ERK1/2, already detectable after 5-min incubation and confirmed by the demonstration that not only ERK1/2 phosphorylation but also CSC induced TJ disassembly and DNA fragmentation were partially inhibited by a mitogen activated protein kinase kinase inhibitor ( U0126 ) and completely blocked by a EGFR inhibitor ( AG1478 )
Luo et al., Oncogene 2011 : Ectopic expression of constitutively active mitogen activated protein kinase kinase 1 ( MKK1 ) resulted in activation of ERK1/2 and partially prevented CPX inhibition of LEC tube formation
Yang et al., Genetics and molecular research : GMR 2012 (MAP Kinase Signaling System) : Constitutive activation of the mitogen activated protein kinase kinase 1 ( CaMEK ) can promote ERK1/2 expression, which is thereby expected to exert protective action on the heart against ischemia-reperfusion injury
Ludwig et al., J Biol Chem 1998 : ERK activation is strongly enhanced by overexpression of p38 and mitogen activated protein kinase kinase 6 ( MKK6 ) but is blocked by dominant negative kinase versions of p38 and MKK6 or the specific p38 inhibitor SB203580