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CASP8 — TNFRSF1B
Text-mined interactions from Literome
Fotin-Mleczek et al., J Cell Sci 2002
(Rhabdomyosarcoma) :
Apoptotic crosstalk of TNF receptors :
TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1 dependent
activation of
caspase-8
Jiang et al., Neuroscience 2005
(Diabetes Mellitus, Experimental) :
Differential
effect of
p75 neurotrophin receptor on expression of pro-apoptotic proteins c-jun, p38 and
caspase-3 in dorsal root ganglion cells after axotomy in experimental diabetes
Al-Lamki et al., J Am Soc Nephrol 2008
(Nephritis) :
Addition of TL1A to organ cultures of human or mouse kidney caused activation of NF-kappaB, expression of
TNFR2 ,
activation of
caspase-3 , and apoptosis in TEC
Joussen et al., Molecular vision 2009
(Diabetic Retinopathy...) :
Etanercept suppressed
caspase activation, retinal cell injury, and apoptosis in short-term diabetic rats
Ji et al., Arterioscler Thromb Vasc Biol 2012
:
While
TNFR2 containing the TNFR associated factor-2 binding sites prevents EC cell death, a specific activation of JNK without NF-?B activation by TNFR2-59 strongly
induces caspase activation and EC apoptosis