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CDK18 — EPHB2
Text-mined interactions from Literome
Alldridge et al., Exp Cell Res 2003
(MAP Kinase Signaling System) :
Moreover, ANXA1 reduces proliferation by
ERK mediated disruption of the actin cytoskeleton and ablation of cyclin D1 protein expression and not by ERK mediated induction of the
cyclin dependent kinase , CDK2, inhibitor p21 ( cip/waf )
Saito et al., J Exp Med 2010
(Cell Transformation, Neoplastic...) :
In nonpolarized epithelial cells,
Erk activation
results in oncogenic stress, up-regulation of the p21 ( Waf1/Cip1 )
cyclin dependent kinase inhibitor, and induction of senescence
Hong et al., Exp Cell Res 2011
(Prostatic Neoplasms) :
Ectopic expression of a constitutively active AR inhibited
Raf/MEK/ERK mediated regulation of the differentiation markers, neuron-specific enolase and neutral endopeptidase, and the
cyclin dependent kinase inhibitors, p16(INK4A) and p21 ( CIP1 ), but not Rb phosphorylation and E2F1 expression, indicating that AR has a specific role in the pathway mediated differentiation and growth inhibitory signaling