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DAB2 — EPHB2

Text-mined interactions from Literome

Zhou et al., J Biol Chem 2001 : DOC-2/DAB2 mediated inhibition of ERK phosphorylation via binding to Grb2 ... We conclude that DOC-2/DAB2 , a potent negative regulator, can suppress ERK activation by interrupting the binding between Grb2 and SOS that is elicited by peptide growth factors
Tseng et al., Biochem Biophys Res Commun 2001 : To determine the involvement of MEK1-p42/p44 MAPK pathway in mediating DAB2 gene expression, we have performed the following experiments and found that ( i ) there was sustained activation of p42/p44 MAPK, but not p38 MAPK, upon K562 cells differentiation ; ( ii ) application of MEK1 inhibitor U0126 reduced the expression of DAB2 protein, mRNA and promoter activity, as well as cell differentiation ; ( iii ) constitutively active MEK1 increased DAB2 promoter activity ; and ( iv ) dominant negative ERK2 abolished constitutively active MEK1 induced DAB2 promoter activity
Kumbar et al., J Appl Physiol 2007 (Cardiomegaly...) : Overexpression of DOC-2 in cardiac fibroblasts led to inhibition of hypertrophy agonist stimulated ERK activation and collagen expression