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IL23A — IL6
Text-mined interactions from Literome
Fuss et al., Inflamm Bowel Dis 2006
(Crohn Disease) :
Finally, we found that
IL-23 induced T cell production of IL-17 and
IL-6 are also greatly reduced after antibody treatment
Zhou et al., Nat Immunol 2007
:
T helper cells that produce interleukin 17 ( IL-17 ; ` T ( H ) -17 cells ' ) are a distinct subset of proinflammatory cells whose in vivo function requires
IL-23 but whose in vitro differentiation
requires only
IL-6 and transforming growth factor-beta ( TGF-beta )
Rachitskaya et al., J Immunol 2008
:
Th17 cells
require IL-6 and TGFbeta for lineage commitment and
IL-23 for maintenance
Cheung et al., J Immunol 2008
(Inflammation) :
IL-17A, IL-17F, and
IL-23 could
induce the release of chemokines GRO-alpha/CXCL1, IL-8/CXCL8, and MIP-1beta/CCL4 from eosinophils, while IL-17F and IL-23 could also increase the production of proinflammatory cytokines IL-1beta and
IL-6
Annunziato et al., Blood 2009
(Autoimmune Diseases) :
While murine Th17 cells develop in response to
IL-6 , IL-1, and transforming growth factor ( TGF ) -beta, human Th17 cells originate from these CD161 ( + ) precursors in
response to IL-1beta and
IL-23 , the need for TGF-beta being controversial
Morishima et al., Biochem Biophys Res Commun 2009
:
TGF-beta and
IL-6 induce Th17 differentiation, and
IL-23 is
required for expansion and maintenance of Th17 cells
Radstake et al., PloS one 2009
(Disease Progression...) :
In line with these observation, circulating levels of IL-17
inducing cytokines
IL-6 ,
IL-23 and IL-1alpha were increased in all or subsets of SSc patients
Myer et al., Exp Gerontol 2010
:
There were relatively minor age related changes in TGF-ß and
IL-6 which promote Th17 differentiation, but
IL-23 , a Th17-suvival cytokine,
increased more than 40-fold across the lifespan
Novitskiy et al., Cancer Discov 2011
(Breast Neoplasms...) :
During polyoma middle T ( PyMT ) induced tumor progression, levels of Th17 inducing cytokines TGF-ß,
IL-6 ,
IL-23 were
increased in PyMT/Tgfbr2 ( KO ) tumors, which was associated with an increased number of Th17 cells