◀ Back to INS

FASN — INS

Text-mined interactions from Literome

Sul et al., J Nutr 2000 : Regulation of the fatty acid synthase promoter by insulin ... By using adipocytes in culture and transgenic mice that express the reporter gene driven by the fatty acid synthase promoter, the cis acting sequence that mediates insulin regulation of the fatty acid synthase promoter was defined ... Using specific inhibitors and expressing various signaling molecules, we found that insulin regulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol (PI)3-kinase signaling pathway and that protein kinase B/akt is a downstream effector
Moon et al., J Biol Chem 2000 : Two 5'-regions are required for nutritional and insulin regulation of the fatty-acid synthase promoter in transgenic mice
Yin et al., J Anim Sci 2001 : Analysis of the signal pathways involved in the regulation of fatty acid synthase gene expression by insulin and somatotropin
Palmer et al., Biochem Biophys Res Commun 2002 : Insulin stimulated fatty acid synthase gene expression does not require increased sterol response element binding protein 1 transcription in primary adipocytes
Barthel et al., Naunyn Schmiedebergs Arch Pharmacol 2002 : Concentration dependent stimulatory and inhibitory effect of troglitazone on insulin induced fatty acid synthase expression and protein kinase B activity in 3T3-L1 adipocytes
Freake et al., J Nutr Sci Vitaminol (Tokyo) 2003 : Thyroid hormone ( 1 microM ) stimulated lipogenesis and acetyl-CoA carboxylase, fatty acid synthase , and S14 mRNA levels up to 2-fold in both types of adipocyte in the presence or absence of insulin
Louveau et al., J Endocrinol 2004 : GH and insulin affect fatty acid synthase activity in isolated porcine adipocytes in culture without any modifications of sterol regulatory element binding protein-1 expression ... Glucose incorporation and fatty acid synthase activity were increased by insulin in a dose dependent manner in adipocytes of both sites
Lagathu et al., Antivir Ther 2004 (HIV-Associated Lipodystrophy Syndrome...) : Lipid metabolism was estimated by Oil Red O staining of intracellular lipids, mRNA expression of fatty acid synthase and adipocyte lipid binding protein 2, and insulin activation of lipogenesis
Griffin et al., IUBMB Life 2004 : Insulin regulation of fatty acid synthase gene transcription : roles of USF and SREBP-1c
Teruel et al., Diabetologia 2005 : Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin induced fatty acid synthase gene expression in brown adipocytes of Wistar rats
Zhang et al., Biochem J 2006 : The inhibitory effect of resveratrol on insulin signalling is also demonstrated at mRNA level, where resveratrol reverses insulin effects on phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, fatty acid synthase and glucokinase
Hansmannel et al., Biochem J 2006 : Insulin induction of glucokinase and fatty acid synthase in hepatocytes : analysis of the roles of sterol-regulatory-element binding protein-1c and liver X receptor
MacDonald et al., Arch Biochem Biophys 2008 : Inhibitors of ACC and fatty acid synthase inhibited insulin release in islets and INS-1 cells
Radenne et al., Am J Physiol Endocrinol Metab 2008 : Hepatic regulation of fatty acid synthase by insulin and T3 : evidence for T3 genomic and nongenomic actions
Katsurada et al., Eur J Biochem 1990 (Diabetes Mellitus, Experimental) : Thus, it is suggested that insulin mainly stimulates the transcription of the fatty acid synthase gene, whereas triiodothyronine and fructose mainly increase the mRNA stability
Roncero et al., Biochim Biophys Acta 1989 : Both hormones, in the presence of insulin , increased lipogenesis and fatty acid synthase activity
Foufelle et al., Eur J Biochem 1994 : A beta-agonist, isoproterenol totally inhibits the inductive effect of glucose and insulin on acetyl-CoA carboxylase and fatty-acid synthase expression whereas it increases the expression of phosphoenolpyruvate carboxykinase ... Similarly, glucagon and cAMP have antagonistic effects on glucose and insulin induced fatty-acid synthase expression
Wolf et al., Biochem Biophys Res Commun 1994 (Carcinoma, Hepatocellular...) : Here we show that insulin may play a role in the diet induced regulation of the rat fatty acid synthase ( FAS ; EC 2.3.1.85 )
Wolf et al., Nutr Rev 1996 : Insulin also increases the synthesis of fatty acid synthase , while glucagon causes a decline
M'Zali et al., Metabolism 1997 : Besides contributing to an accumulation of larger and numerous lipid droplets in the cells, insulin increased fatty acid synthase activity by 26 %, whereas malic enzyme was not affected
Wang et al., J Biol Chem 1997 : Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter ... These results demonstrate that upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter
Klemm et al., J Biol Chem 1998 : Finally, we demonstrate an essential role for CREB in insulin activation of fatty-acid synthase and fatty acid binding protein (FABP) indicating the potential physiologic relevance of insulin regulation of CREB
Porras et al., Mol Endocrinol 1998 : Moreover, transient expression of a transfected active MEK construct ( R4F ) decreased IGF-I induced UCP-1 and insulin induced fatty acid synthase mRNA expression