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Kremerskothen et al., Neurosci Lett 2002
(Neuroblastoma) :
Insulin induced expression of the activity regulated cytoskeleton associated gene (
ARC ) in human neuroblastoma cells requires p21(ras), mitogen activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Malabu et al., Peptides 1992
(Body Weight) :
We tested the hypothesis that low plasma
insulin levels
stimulate ARC levels of NPY in fasted rats
Gopalakrishnan et al., Biochem Cell Biol 2006
(Diabetes Mellitus, Experimental) :
In the vertebrae,
TRAP activity was elevated as a result of diabetes, but this was
prevented by
insulin or estradiol
Schwartz et al., Endocrinology 1991
(Obesity) :
Thus,
insulin reduced the expression of mRNA for NPY specifically in the
ARC
Newman et al., Endocrinology 1985
:
Mediator generation was rapid, with a half-time of approximately 45 sec and was
insulin dose
dependent