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RGS4 — VEGFA
Text-mined interactions from Literome
Albig et al., Mol Biol Cell 2005
:
Identification and characterization of regulator of G protein signaling 4 ( RGS4 ) as a novel inhibitor of tubulogenesis :
RGS4 inhibits mitogen activated protein kinases and
vascular endothelial growth factor signaling ... RGS4 had no effect on the phosphorylation of Smad1 and Smad2 by bone morphogenic protein-7 and transforming growth factor-beta, respectively, indicating that
RGS4 selectively
inhibits G protein and
VEGF signaling in endothelial cells
Aguilar et al., Cancer Res 2012
(Cell Transformation, Viral) :
Mechanistic investigations revealed that
RGS4 reduced vGPCR enhanced cell proliferation, migration,
VEGF expression, and Akt activation and suppressed tumor formation induced by vGPCR