◀ Back to RAC1

LEP — RAC1

Text-mined interactions from Literome

Mattioli et al., FASEB J 2008 : We found that in immature DCs, leptin activates cofilin, favoring the turnover of actin microfilaments, and, by triggering Vav phosphorylation, promotes Rac1 activation
Jaffe et al., Int J Cancer 2008 (Colonic Neoplasms...) : A direct and novel dose- and time dependent activation of RhoA, Cdc42 and Rac1 by leptin is demonstrated in these aggressive colon cancer cells ... The activation of the Rho family of GTPases was amenable to specific inhibition : Wortmannin inhibited leptin induced Rac1 and Cdc42 activation but did not affect RhoA activation, and inhibited the formation of leptin induced lamellipodia and cell invasion ... The Rac1 inhibitor NSC23766 inhibited only leptin induced Rac1 activation and concomitantly, lamellipodium formation and cell invasion ... The specific JAK2 inhibitor AG490 exerted a positive effect on Rac1 and Cdc42 activation by leptin and concomitantly inhibited RhoA activation
Jiang et al., Hepatology 2008 : We found that leptin induced the PI3K dependent activation of Rac1 , and that nicotinamide adenine dinucleotide phosphate, reduced form ( NADPH ) oxidase activation was also implicated in this process
Zeidan et al., Mol Cell Biochem 2011 : The specific mTOR inhibitor rapamycin ( 10 nM ) attenuated leptin induced RhoA and Rac1 activation
Shyu et al., Clin Sci (Lond) 2012 : The inhibitory effect of atorvastatin on Ang II-induced leptin expression was mediated by Rac , ROS and JNK pathways