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RECK — TIMP2

Pathways - manually collected, often from reviews:

• BioCarta inhibition of matrix metalloproteinases: TIMP2/ProMMP-2 complex (TIMP2) → RECK (modification, collaborate)
• BioCarta inhibition of matrix metalloproteinases: RECK → TIMP2 (modification, inhibits)

Text-mined interactions from Literome

Oh et al., Cancer Res 2004 (Melanoma) : TIMP-2 induced RECK decreases cell associated MMP activity ... The effects of TIMP-2 on RECK expression and cell migration were confirmed in A2058 melanoma cells ... Third, TIMP-2 can enhance expression of RECK via Rap1 signaling resulting in an indirect, time dependent inhibition of endothelial cell migration
Oh et al., Oncogene 2006 : TIMP-2 upregulates RECK expression via dephosphorylation of paxillin tyrosine residues 31 and 118 ... We previously demonstrated that TIMP-2 increases the association of Crk with C3G and via subsequent activation of Rap1 enhances the expression of RECK , a membrane anchored MMP inhibitor