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APOB — APOE

Pathways - manually collected, often from reviews:

• Reactome Reaction: APOB → APOE (indirect_complex) Futamura et al., J Biol Chem 2005, Yamauchi et al., Biochemistry 2008, Ji et al., J Biol Chem 1993, Ji et al., J Biol Chem 1994*
• Reactome Reaction: APOB → APOE (reaction) Futamura et al., J Biol Chem 2005, Yamauchi et al., Biochemistry 2008, Gad et al., J Lipid Res 1991, Harrison et al., J Biol Chem 1989, Ji et al., J Biol Chem 1994*, Hagen et al., J Lipid Res 1999

Text-mined interactions from Literome

Barbagallo et al., Arterioscler Thromb Vasc Biol 1999 (Hypercholesterolemia) : In contrast, apoE transgenic rabbits had a marked reduction in the levels of large VLDLs, with a selective accumulation of IDLs and large buoyant LDLs. Combined expression of apoE and HL led to dramatic reductions of total cholesterol ( 85 % versus controls ) and of total VLDL+IDL+LDL ( 87 % versus controls )
Van Eck et al., Atherosclerosis 2001 (Arteriosclerosis) : This low level of apoE nevertheless reduced VLDL and LDL cholesterol 12-fold ( P < 0.001 ) and fourfold ( P < 0.001 ), respectively, thereby reducing serum cholesterol levels and the susceptibility to atherosclerosis
Elsegood et al., Clin Sci (Lond) 2001 : The high-molecular-mass binding site was found to be the low-density lipoprotein (LDL) receptor, based on the strong inhibition of chylomicron remnant binding in the presence of unlabelled LDL , Fab2 antibody fragments to the LDL receptor or calcium chelators
DeWille et al., Dev Neurosci 1992 (Body Weight) : In contrast to brain, nursing pup hepatic SCD mRNA levels were induced, LDL receptor mRNA levels were unaffected and Apo E mRNA levels were reduced by postnatal maternal fat-free feeding
Ye et al., J Biol Chem 1992 : In pulse-chase experiments, the LDL effect on apoE accumulation in the media was observed when it was added only during the chase even in the presence of cycloheximide, indicating that LDL is functioning at a post-translational level ... The addition of protease inhibitors could not duplicate the effects of LDL on the apoE accumulation in the medium
Black et al., Biochem J 1992 : Apo B may be specifically down-regulated by the chylomicron secretory blockade induced by Pluronic L-81
Gusarova et al., J Biol Chem 2007 : Golgi associated maturation of very low density lipoproteins involves conformational changes in apolipoprotein B , but is not dependent on apolipoprotein E
Ribas et al., Proc Natl Acad Sci U S A 2011 (Atherosclerosis...) : In isolated macrophages, ERa was necessary for repression of inflammation, maintenance of oxidative metabolism, IL-4 mediated induction of alternative activation, full phagocytic capacity in response to LPS, and oxidized LDL induced expression of ApoE and Abca1
Ishikawa et al., J Biol Chem 1988 : A change in apolipoprotein B expression is required for the binding of apolipoprotein E to very low density lipoprotein
Funahashi et al., J Biochem 1989 : ApoE in the form of the self associated tetramer did not inhibit binding of human low density lipoprotein (LDL) to its receptor on cultured human skin fibroblast
Gabelli et al., J Lipid Res 1986 (Hyperlipoproteinemia Type III) : ApoE deficiency resulted in an accumulation of plasma IDL, and a decreased synthesis of LDL consistent with a block in the conversion of IDL to LDL
Bradley et al., J Biol Chem 1984 (Hyperlipoproteinemias) : We conclude that apo-E of the thrombin-accessible conformation mediates uptake of HTG-VLDL1 and HTG-VLDL2 but that apo-B alone is sufficient to mediate receptor binding of IDL and LDL ; the switch from apo-E to apo-B as the primary or sufficient binding determinant occurs within the VLDL3 ( Sf 20-60 ) region of the metabolic cascade, where receptor binding first appears in VLDL subclasses from normal subjects
Colaco et al., Bioessays 1994 (Arteriosclerosis) : We hypothesise that the covalent binding of glycated LDL to the endothelial cell wall may result in the formation of the early atherosclerotic lesion of the fatty streak and that apolipoprotein E may mediate the physiological clearance of glycated moieties
Mann et al., Eur J Clin Invest 1995 (Hyperlipidemias) : The authors determine in this paper the effect of ApoE and LpL on chylomicron and LDL binding and uptake by human hepatocytes in primary culture
Levy et al., FEBS Lett 1996 : Adding insulin ( 3 mU ) to the serum-free medium of cultured jejunal explants from human fetuses ( 17-20 weeks ) reduced triglyceride and chylomicron production and inhibited apo B-48 and apo B-100 secretion
Klausen et al., J Mol Med (Berl) 1996 (Body Weight...) : The expected effects of both apoE and apoB polymorphism on LDL levels were significant in the whole population sample and in subjects with large sized apo(a) isoforms ( P < 0.01 ), whereas no effect was seen in those with low molecular weight apo(a) isoforms
Cader et al., J Lipid Res 1997 : These results elucidate a potential role of oxidized LDL , and specifically 7-ketocholesterol, in the stimulation of macrophage apoE secretion in atherosclerotic lesions
Taggart et al., Diabet Med 1997 (Diabetes Mellitus, Type 2) : The postprandial chylomicron apolipoprotein B48 response of both diabetic and control subjects to the cholesterol meal was less than to the cholesterol-free meal ( p < 0.001 )
Ou et al., Atherosclerosis 1998 (Coronary Disease) : Apolipoprotein E4 increases plasma LDL-cholesterol levels
Swarnakar et al., J Biol Chem 1998 : In terms of cholesterol delivery to the adrenal cell, the apoE mediated enhancement of LDL-CE selective uptake was quantitatively more important
Paragh et al., Metabolism 1998 (Diabetes Mellitus, Type 2...) : The LDL induced inhibition of endogenous cholesterol synthesis and the acLDL triggered apolipoprotein ( apo ) E secretion were also studied, as the biological marker of receptor activation