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GRAP2 — PTPN11
Text-mined interactions from Literome
Pearson et al., Virology 2000
:
In addition, we show that very low levels of wild-type
NS1 were able to significantly
transactivate P38
Deleu et al., J Gen Virol 2001
:
This mutant provided evidence that
transactivation of the parvoviral
P38 promoter and transinhibition of a heterologous promoter by
NS1 were both affected by the co-expression of the wt and the dominant negative mutant form of NS1
Ahn et al., J Virol 1992
:
These results suggest that
NS1 transactivates the
P38 promoter indirectly by interacting with one or more components of the P38 core-transcription complex
Gu et al., Virology 1992
:
It was previously shown that the parvovirus H-1 nonstructural protein
NS1 positively
regulates the expression of the
P38 promoter for the viral capsid protein gene via the tar
Hanson et al., J Virol 1991
:
NS1 trans-activates the
P38 promoter for capsid protein synthesis and has variable effects on other promoters
Mamik et al., PloS one 2012
:
Furthermore,
SHP2 overexpression
resulted in higher SHP2 and
p38 enzyme activity whereas p38 overexpression resulted in higher p38 but not SHP2 enzyme activity
Rhode et al., J Virol 1987
(Chromosome Deletion) :
The parvovirus early protein
NS1 positively
regulates the expression of the
P38 promoter for the viral capsid protein gene
Lorson et al., J Virol 1996
:
The
P38 promoter of the autonomous parvovirus minute virus of mice is strongly
transactivated by the nonstructural protein
NS1 , a sequence-specific DNA binding protein ... In the context of the complete viral genome, the only unique cis acting signals required for
P38 transactivation by
NS1 are the proximal Sp1 site and the TATA element
Harris et al., J Virol 1999
:
NS1 transactivates the
P38 promoter ( used to express the structural proteins ), as well as its own strong promoter, P4