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JAK1 — TPO
Text-mined interactions from Literome
Wang et al., Blood 2000
:
Previous studies indicated that
Janus kinase ( JAK ) and its substrates
mediate the effects of
TPO on cellular proliferation and survival
Kuter et al., Int J Hematol 2013
:
TPO binds the TPO receptor,
activates JAK and STAT pathways, thus stimulating megakaryocyte growth and platelet production
Dorsch et al., Biochem Biophys Res Commun 1995
:
Whereas phosphorylation of these proteins was induced by both cytokines, phosphorylation of
Jak1 was
induced only by IL-3 and not by
TPO , distinguishing the signal transduction of the two cytokines on a molecular level
Leven et al., Blood Cells Mol Dis 1997
:
Studies on protein phosphorylation revealed that IL6, but not
TPO ,
stimulated phosphorylation of
JAK1 , JAK2 and MAP kinase ... Studies on protein phosphorylation revealed that IL6, but not
TPO ,
stimulated phosphorylation of JAK1,
JAK2 and MAP kinase