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CALM2 — CALM3
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
CALM2, CALM3, CALM1
—
CALM2, CALM3, CALM1
(x-ray crystallography)
-
MIPS CORUM H2AX complex, isolated from cells without IR exposure:
H2AX complex, isolated from cells without IR exposure complex (CALM2-CALM3-CALM1-CALR-EIF3L-H2AFX-HIST1H4C-HIST1H4B-HIST1H4A-HIST4H4-HIST1H4F-HIST1H4E-HIST1H4D-HIST1H4K-HIST1H4J-HIST1H4I-HIST1H4H-HIST1H4L-HIST2H4B-HIST2H4A-HIST3H2BB-HNRNPR-HSPA5-NPM1-PABPC1-SSB-SSRP1-SUPT16H)
Du et al., Mol Cell Proteomics 2006
-
MIPS CORUM TGM2-HD-CALM1 complex:
TGM2-HD-CALM1 complex complex (CALM2-CALM3-CALM1-HTT-TGM2)
Zainelli et al., J Neurosci 2004*
-
MIPS CORUM HSP90-FKBP38-CAM-Ca(2+) complex:
HSP90-FKBP38-CAM-Ca(2+) complex complex (CALM2-CALM3-CALM1-FKBP8-HSP90AA1-HSP90AB1)
Edlich et al., J Biol Chem 2007
-
MIPS CORUM YWHAQ-CALM1-CABIN1 complex:
YWHAQ-CALM1-CABIN1 complex complex (CABIN1-CALM2-CALM3-CALM1-YWHAQ)
Pan et al., EMBO J 2005
-
MIPS CORUM CALM1-FKBP38-BCL2 complex:
CALM1-FKBP38-BCL2 complex complex (BCL2-CALM2-CALM3-CALM1-FKBP8)
Edlich et al., EMBO J 2005
-
MIPS Negatome - no physical interaction between proteins Interaction:
CALM2, CALM3, CALM1
—
CALM2, CALM3, CALM1
(Absence of interaction, coimmunoprecipitation; MI:0096)
Gao et al., Genomics 2008
Text-mined interactions from Literome
Tamura et al., Cancer 2000
(Carcinoma, Hepatocellular...) :
Ca ( 2+ )
/calmodulin dependent
CaM-kinase IV activity was high in HCC and showed almost no difference in activity in specimens with and without CaM-kinase kinase phosphorylation
Wu et al., J Physiol 2001
:
1.
Ca2+-calmodulin dependent protein kinase II ( CaMK ) and a
calmodulin (CaM) binding ` IQ ' domain ( IQ ) are both implicated in Ca2+ dependent regulation of L-type Ca2+ current ( I ( Ca ) )
Dupont et al., Cell Calcium 2003
:
The rules that govern the
activation and autophosphorylation of the multifunctional
Ca2+-calmodulin kinase II ( CaMKII ) by Ca2+ and
calmodulin (CaM) are thought to underlie its ability to decode Ca2+ oscillations and to control multiple cellular functions
Apel et al., J Biol Chem 1991
:
Calmodulin inhibition of casein kinase II phosphorylation was
due to
calmodulin binding to neuromodulin rather than to the protein kinase
Lavialle-Defaix et al., J Pharmacol Exp Ther 2010
(Ion Channel Gating) :
Furthermore, we demonstrated that
activation of
CaM-kinase II by intracellular calcium via the
calcium-calmodulin complex affected the sensitivity of INa2 channels to DCJW
Yokoyama et al., Cell Calcium 1989
:
Ca2+/calmodulin dependent
activation of
CaM-PPase was antagonized by inhibitors of calmodulin action, such as W-7 and trifluoperazine
Alexander et al., J Biol Chem 1987
:
CaM decreased the rate of phosphorylation of P-57 by protein kinase C, and phosphorylation
prevented P-57 binding to
calmodulin-Sepharose
Jett et al., Arch Biochem Biophys 1987
:
These data indicate that the membrane bound, calmodulin dependent protein kinase that phosphorylates phospholamban in cardiac membranes is not a specific
calmodulin dependent kinase, but resembles the multifunctional
Ca2+/CaM-kinase II
Widmaier et al., Endocrinology 1987
(Adrenal Gland Neoplasms) :
Calmodulin binding was
inhibited by competition with unlabeled calmodulin and by an inhibitor of
calmodulin ( trifluoperazine )
Friedman et al., Biochem Biophys Res Commun 1986
:
PK-CaM , using casein as exogenous substrate, was not
stimulated by Ca2+ ( 0-500 microM ) or
calmodulin ( 1-10 micrograms ) by themselves, but was stimulated by the combination of the two by 100 %
Iida et al., Curr Genet 1995
:
Calmodulin dependent protein kinase II and
calmodulin are required for induced thermotolerance in Saccharomyces cerevisiae
Hohenegger et al., Biochem J 1993
:
In the present study, we have examined the ability of the purified cardiac ryanodine receptor to serve as a substrate for phosphorylation by exogenously added catalytic subunit of the cyclic AMP ( cAMP ) -dependent protein kinase (PK-A), cyclic GMP ( cGMP ) -dependent protein kinase ( PK-G ), or
calmodulin dependent protein kinase (
PK-CaM )
Ivorra et al., Br J Pharmacol 1993
:
Antioquine weakly inhibited some PDE forms isolated from bovine aorta : a
CaM-PDE ( PDE I ) which preferentially hydrolyzes cyclic GMP and is
activated by
calmodulin , and a rolipram-sensitive cyclic AMP-PDE ( PDE IV ) which hydrolyzed cyclic AMP
Kawano et al., Circ Res 1993
:
In the presence of
calmodulin ( CaM, 0.1 mumol/L per microgram SR vesicles ), Ca2+ ( 3 mumol/L to 1 mmol/L ) added to the cis solution
reduced the channel openings in a concentration dependent fashion, whereas Ca2+ ( 1 nmol/L to 1 mmol/L ) alone or
CaM ( 0.1 to 1 mumol/L per microgram SR vesicles ) with 1 nmol/L Ca2+ did not affect the channel activity
Edlund et al., J Biol Chem 1996
:
This suggests that
calmodulin can
regulate the functional activity of
C-CAM
Ozbasli et al., Miner Electrolyte Metab 1996
:
Calmodulin content in pancreatic islets and the
response of islet membrane Ca2+ ATPase to
calmodulin in phosphate depletion
de Freitas et al., Neurochem Res 1996
:
Furthermore, exogenous
Ca2+/calmodulin induced increased in vitro phosphorylation of the cytoskeletal proteins and
CaM-KII activity only in the presence of calpastatin, suggesting the presence of Ca ( 2+ ) -induced calpain mediated proteolysis