Gene interactions and pathways from curated databases and text-mining

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CALM2 — CALM3

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Tamura et al., Cancer 2000 (Carcinoma, Hepatocellular...) : Ca ( 2+ ) /calmodulin dependent CaM-kinase IV activity was high in HCC and showed almost no difference in activity in specimens with and without CaM-kinase kinase phosphorylation
Wu et al., J Physiol 2001 : 1. Ca2+-calmodulin dependent protein kinase II ( CaMK ) and a calmodulin (CaM) binding ` IQ ' domain ( IQ ) are both implicated in Ca2+ dependent regulation of L-type Ca2+ current ( I ( Ca ) )
Dupont et al., Cell Calcium 2003 : The rules that govern the activation and autophosphorylation of the multifunctional Ca2+-calmodulin kinase II ( CaMKII ) by Ca2+ and calmodulin (CaM) are thought to underlie its ability to decode Ca2+ oscillations and to control multiple cellular functions
Apel et al., J Biol Chem 1991 : Calmodulin inhibition of casein kinase II phosphorylation was due to calmodulin binding to neuromodulin rather than to the protein kinase
Lavialle-Defaix et al., J Pharmacol Exp Ther 2010 (Ion Channel Gating) : Furthermore, we demonstrated that activation of CaM-kinase II by intracellular calcium via the calcium-calmodulin complex affected the sensitivity of INa2 channels to DCJW
Yokoyama et al., Cell Calcium 1989 : Ca2+/calmodulin dependent activation of CaM-PPase was antagonized by inhibitors of calmodulin action, such as W-7 and trifluoperazine
Alexander et al., J Biol Chem 1987 : CaM decreased the rate of phosphorylation of P-57 by protein kinase C, and phosphorylation prevented P-57 binding to calmodulin-Sepharose
Jett et al., Arch Biochem Biophys 1987 : These data indicate that the membrane bound, calmodulin dependent protein kinase that phosphorylates phospholamban in cardiac membranes is not a specific calmodulin dependent kinase, but resembles the multifunctional Ca2+/CaM-kinase II
Widmaier et al., Endocrinology 1987 (Adrenal Gland Neoplasms) : Calmodulin binding was inhibited by competition with unlabeled calmodulin and by an inhibitor of calmodulin ( trifluoperazine )
Friedman et al., Biochem Biophys Res Commun 1986 : PK-CaM , using casein as exogenous substrate, was not stimulated by Ca2+ ( 0-500 microM ) or calmodulin ( 1-10 micrograms ) by themselves, but was stimulated by the combination of the two by 100 %
Iida et al., Curr Genet 1995 : Calmodulin dependent protein kinase II and calmodulin are required for induced thermotolerance in Saccharomyces cerevisiae
Hohenegger et al., Biochem J 1993 : In the present study, we have examined the ability of the purified cardiac ryanodine receptor to serve as a substrate for phosphorylation by exogenously added catalytic subunit of the cyclic AMP ( cAMP ) -dependent protein kinase (PK-A), cyclic GMP ( cGMP ) -dependent protein kinase ( PK-G ), or calmodulin dependent protein kinase ( PK-CaM )
Ivorra et al., Br J Pharmacol 1993 : Antioquine weakly inhibited some PDE forms isolated from bovine aorta : a CaM-PDE ( PDE I ) which preferentially hydrolyzes cyclic GMP and is activated by calmodulin , and a rolipram-sensitive cyclic AMP-PDE ( PDE IV ) which hydrolyzed cyclic AMP
Kawano et al., Circ Res 1993 : In the presence of calmodulin ( CaM, 0.1 mumol/L per microgram SR vesicles ), Ca2+ ( 3 mumol/L to 1 mmol/L ) added to the cis solution reduced the channel openings in a concentration dependent fashion, whereas Ca2+ ( 1 nmol/L to 1 mmol/L ) alone or CaM ( 0.1 to 1 mumol/L per microgram SR vesicles ) with 1 nmol/L Ca2+ did not affect the channel activity
Edlund et al., J Biol Chem 1996 : This suggests that calmodulin can regulate the functional activity of C-CAM
Ozbasli et al., Miner Electrolyte Metab 1996 : Calmodulin content in pancreatic islets and the response of islet membrane Ca2+ ATPase to calmodulin in phosphate depletion
de Freitas et al., Neurochem Res 1996 : Furthermore, exogenous Ca2+/calmodulin induced increased in vitro phosphorylation of the cytoskeletal proteins and CaM-KII activity only in the presence of calpastatin, suggesting the presence of Ca ( 2+ ) -induced calpain mediated proteolysis