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GJA1 — IFI27

Text-mined interactions from Literome

Zhang et al., Cancer Res 2003 : However, ectopic expression of Skp2 reversed the Cx43 induced Skp2 reduction, p27 accumulation, and cell proliferation inhibition ... Cx43 increased p27 expression only in the SKP2 +/+ mouse embryo fibroblasts ( MEFs ), but not in the SKP2 -/- MEFs, indicating that Skp2 plays a critical role in the Cx43 induced p27 up-regulation ... We also show that both Skp2 and p27 are required for Cx43 to inhibit cell proliferation, in that Cx43 hardly inhibited cell proliferation of the SKP2 -/- and p27 -/- MEFs, whereas it clearly did both in the SKP2 +/- and in the p27 +/- MEFs
Zhang et al., J Am Soc Nephrol 2006 : Knocking down Cx43 gene expression significantly increased the percentage of SA-beta-gal stained cells and p27kip1 and p21cip1 expression in GMC ( P < 0.05 ), whereas overexpression of Cx43 significantly decreased the percentage of SA-beta-gal stained cells ( P < 0.05 )