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MMP14 — RAC1

Text-mined interactions from Literome

Zhuge et al., J Biol Chem 2001 (Carcinoma, Squamous Cell...) : The Rac1 dependent MMP-2 activation occurred in a cell associated fashion and required MMP activities
Kamioka et al., J Cell Physiol 2011 (Atherosclerosis) : AGE induced geranylgeranyl transferase I ( GGTase I ) activity, Rac1·p47(phox) activation, NADPH oxidase activity, ROS generation, and molecular expression were also markedly attenuated by silencing of MT1-MMP
Ando et al., J Atheroscler Thromb 2011 : In this study, we hypothesized that MT1-MMP may mediate RhoA and Rac1 activation and their downstream events in thrombin stimulated endothelial cells ... Silencing of MT1-MMP attenuated thrombin triggered RhoA and Rac1 activation, resulting in the attenuation of downstream events including Ca ( 2+ ) signaling, NADPH oxidase activity, ROS generation, and TF and PAI-1 expression ... The present study shows that MT1-MMP mediates the RhoA/Ca ( 2+ ) and Rac1/NADPH oxidase dependent signaling pathways in thrombin induced vascular responses
Huang et al., PloS one 2012 (Breast Neoplasms...) : Inhibition of PKC?, Rac-1 and phosphatidylinositol 3-kinase may attenuate MT1-MMP expression in cells exposed to HGF
Stallings-Mann et al., Sci Transl Med 2012 (Adenocarcinoma...) : We show that expression of mouse Rac1b in lung epithelial cells of transgenic mice stimulated EMT and spontaneous tumor development and that activation of EMT by MMP induced expression of Rac1b gave rise to lung adenocarcinoma in the transgenic mice through bypassing oncogene induced senescence
Serratì et al., Arthritis Rheum 2013 (Scleroderma, Systemic) : Motility increase required Rac1 activation and RhoA inhibition and was inhibited by an MMP inhibitor