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EPHB2 — PAK1

Pathways - manually collected, often from reviews:

• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB2/KALRN complex (EFNB3_EFNB2_EFNB1-EPHB2-KALRN) → PAK1 (PAK1) (modification, activates) Penzes et al., Neuron 2003
  Evidence: mutant phenotype, other species
• Reactome Reaction: PAK1 → EPHB2 (reaction) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005
• Reactome Reaction: PAK1 → EPHB2 (indirect_complex) Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Neurosci 2005

Text-mined interactions from Literome

Wen et al., Biochem J 2000 : Transfection of dominant negative PAK1 blocked 12-HETE induced PAK1, cJun N-terminal kinase ( JNK1 ) and extracellular-signal regulated kinase ( ERK ) activity, while transfection of constitutively active PAK1 stimulated PAK1, JNK1 and ERK activity, suggesting that PAK1 is an upstream activator of 12-HETE induced JNK1 and ERK activation in these cells
Wang et al., Biochemistry 2002 : Moreover, CXCL1 activation of PAK1 is independent of ERK1/2 activation, a conclusion based on the observations that the inhibition of MEK-ERK activation by expression of dominant negative ERK or by the MEK inhibitor, PD98059, has no effect on CXCL1 induced PAK1 activation or CXCL1 induced chemotaxis
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : PAK1 ( p21 activated kinase 1 ) activation is induced by C albicans, suggesting that PAK1 may also be involved in the Rac1 activation of MAPK/ERK
Penzes et al., Neuron 2003 : Overexpression of dominant negative EphB receptor, catalytically inactive kalirin, or dominant negative Rac1, or inhibition of PAK eliminates ephrin induced spine development
Sundberg-Smith et al., J Biol Chem 2005 : Adhesion stimulates direct PAK1/ERK2 association and leads to ERK dependent PAK1 Thr212 phosphorylation ... Interestingly, deletion of a major ERK binding site in PAK attenuates activation of an ERK dependent serum-responsive element ( SRE ) -luciferase reporter gene, indicating that association between PAK and ERK is required to facilitate ERK signaling
Schmid et al., Neuroreport 2004 (Neuroblastoma) : Also, we found that Pak1 kinase activity contributes to ERK activation by L1, and is necessary for L1-potentiated haptotactic cell migration
Pullikuth et al., Mol Cell Biol 2005 : Here we show that the putative scaffold protein MEK partner 1 (MP1) and its partner p14 regulate PAK1 dependent ERK activation during adhesion and cell spreading but are not required for ERK activation by platelet derived growth factor
Stockton et al., Mol Biol Cell 2007 (Inflammation) : Erk in lipopolysaccharide (LPS) treated mouse lung is activated in a PAK dependent manner in several cell types, most prominently vascular endothelium
Lim et al., Endocrinology 2009 : Knockdown or inhibition of Cdc42 and PAK1 activities also prevented activation of MAPK/ERK (MEK)-1/2-ERK1/2 by insulin, which was previously identified as a critical pathway for insulin regulated GLP-1 release
Yuan et al., Clin Exp Metastasis 2010 (Brain Neoplasms...) : In this study, we investigated whether ERK regulates Rac1/Pak1 signaling and is critically linked to MB cell migration ... However, specific depletion of Pak1 by siRNA has no effect on PDGF induced ERK phosphorylation, indicating that in MB cells ERK signaling is Pak1 independent, but PDGF induced migration is dependent on ERK mediated activation of Pak1 ... We conclude that Rac1/Pak1 signaling is critical to MB cell migration and is functionally dependent on PDGFRß/ERK activity
Chow et al., PloS one 2010 (Cell Transformation, Neoplastic...) : However, in tumors, loss of Pak activity does not reduce Erk or Akt activity, two signaling proteins that are thought to mediate Pak function in growth factor pathways
De la Mota-Peynado et al., J Biol Chem 2011 (MAP Kinase Signaling System) : Erk3 protein is known to shuttle between the cytoplasm and the nucleus, and we showed that selective inhibition of class I Pak kinase activity in cells promoted increased nuclear accumulation of Erk3
Wang et al., J Biol Chem 2013 (MAP Kinase Signaling System) : p21 Activated Kinase 1 (PAK1) Can Promote ERK Activation in a Kinase independent Manner ... We observed how that overexpression of a kinase-dead mutant form of PAK1 increased phosphorylation of MEK1/2 ( Ser-217/Ser-221 ) and ERK ( Thr-202/Tyr-204 ), although phosphorylation of B-RAF ( Ser-445 ) and C-RAF ( Ser-338 ) remained unchanged
Tang et al., Mol Cell Biol 1997 (Cell Transformation, Neoplastic) : Ras activation of ERK was inhibited by both Pak1 ( R299 ) and Pak1 ( L83,L86,R299 ), while neither mutant inhibited Raf activation of ERK
Yablonski et al., EMBO J 1998 : TCR mediated activation of Erk2 was also inhibited by dominant negative Pak ... Therefore, Pak1 acts downstream of Vav and is required for activation of Erk2 and NFAT by a JNK independent pathway