◀ Back to CD4

CD4 — CD44

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: CD44 — CD4 (in vitro) Dianzani et al., Eur J Immunol 1995*
• IRef Ophid Interaction: CD44 — CD4 (aggregation, confirmational text mining) Dianzani et al., Eur J Immunol 1995*
• IRef Ophid Interaction: CD44 — CD4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Dianzani et al., Int Immunol 1999 : CD44 signaling through p56lck involves lateral association with CD4 in human CD4+ T cells
Rabanal et al., Oligonucleotides 2003 : AS-CD4-2 and AS-CD4-4 inhibited T CD4+ cell proliferative response upon antigen-specific and unspecific stimuli
Elyaman et al., Am J Pathol 2008 (Encephalomyelitis, Autoimmune, Experimental) : We found that memory CD4 ( + ) T cells up-regulated the activation marker CD44 as well as CXCR3 and ICOS, proliferated more and produced more interferon-gamma and less interleukin-17 compared to effector T cells
Santiago et al., Immunobiology 2011 : Mucosal CD4 ( + ) CD25 ( + ) Foxp3 ( + ) and CD4 ( + ) LAP ( + ) T cells increased with aging but activated CD44 ( + ) CD4 ( + ) mucosal T cells also augmented
Rankin et al., J Immunol 2012 (Lupus Erythematosus, Systemic...) : Activated CD4 ( + ) CD44 ( + ) CD62L ( lo ) T cells also failed to accumulate, and CD4 ( + ) Th cell differentiation was impaired , as evidenced by a significant reduction in CD4 ( + ) T cells that produced the pronephritogenic cytokine IFN-?
Aroeira et al., Scand J Immunol 1996 : SEB activated spleen CD4+ and CD8V beta 8+ T cells have different population dynamics and regulate the expression of MEL-14 and Pgp-1 differentially, suggesting that the SEB-MHC class II complex preferentially activates CD4V beta 8+ T cells