Gene interactions and pathways from curated databases and text-mining

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CDKN1A — PAK2

Text-mined interactions from Literome

Roig et al., J Biol Chem 1999 : p21 activated protein kinase gamma-PAK is activated by ionizing radiation and other DNA damaging agents
Roig et al., J Biol Chem 2000 : p21 activated protein kinase gamma-PAK is translocated and activated in response to hyperosmolarity
Jakobi et al., Eur J Biochem 2000 : Substrates enhance autophosphorylation and activation of p21 activated protein kinase gamma-PAK in the absence of activation loop phosphorylation
Roig et al., Vitam Horm 2001 : Cytostatic p21 G protein activated protein kinase gamma-PAK
Roig et al., FEBS Lett 2001 : Autophosphorylation of p21 activated protein kinase gamma-PAK is stimulated at 10 microM sphingosine in vitro and is maximal at 100 microM
Tuazon et al., FEBS Lett 2002 : p21 activated protein kinase gamma-PAK phosphorylates prolactin (PRL) in rat pituitary secretory granules on Ser-177 and on the equivalent site, Ser-179, in recombinant human PRL
Brown et al., Mol Biol Cell 2002 : The precise temporal-spatial regulation of the p21 activated serine-threonine kinase PAK at the plasma membrane is required for proper cytoskeletal reorganization and cell motility
Huang et al., J Biol Chem 2003 : Localization of p21 activated protein kinase gamma-PAK/Pak2 in the endoplasmic reticulum is required for induction of cytostasis
Miah et al., Mol Cell Biol 2004 : Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21 activated protein kinase Pak2/gamma-PAK
Foster et al., J Neuroimmune Pharmacol 2011 : The poorly understood Nef functions of p21 activated protein kinase ( PAK2 ) activation, enhancement of virion infectivity, and inhibition of immunoglobulin class switching are also likely to involve ternary complexes and non-canonical interactions
Meshki et al., PloS one 2011 : Although p21 activated kinase (PAK) is expressed in both cell lines, SP induced rapid phosphorylation of PAK in U373MG, but failed to phosphorylate PAK in HEK293-NK1R cells
Walter et al., J Biol Chem 1998 : Cleavage and activation of p21 activated protein kinase gamma-PAK by CPP32 ( caspase 3 ) ... p21 activated protein kinase gamma-PAK ( Pak2, PAK I ) is cleaved by CPP32 ( caspase 3 ) during apoptosis and plays a key role in regulation of cell death
Tuazon et al., Biochemistry 1998 : Autophosphorylation and protein kinase activity of p21 activated protein kinase gamma-PAK are differentially affected by magnesium and manganese