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CTNNB1 — DVL2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Degradation of beta catenin: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/APC//beta catenin complex (AXIN1-APC-CTNNB1) (modification, inhibits)
  Kishida et al., Oncogene 1999, Kodama et al., J Biol Chem 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Orford et al., J Biol Chem 1997, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → beta catenin (CTNNB1) (modification, collaborate) Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: WNT3A/LRP6/FZD5/DVL complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2) → Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: beta catenin (CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• NCI Pathway Database Canonical Wnt signaling pathway: Axin1/APC/GSK3/beta catenin complex (AXIN1-APC-GSK3B_GSK3A-CTNNB1) → WNT3A/LRP6/FZD5/DVL/Axin1/GSK3 complex (WNT3A-LRP6-FZD5-DVL3_DVL1_DVL2-AXIN1-GSK3B_GSK3A) (modification, collaborate)
  Kishida et al., Oncogene 1999, Amit et al., Genes Dev 2002, Cong et al., Mol Cell Biol 2004, Ikeda et al., EMBO J 1998
  Evidence: mutant phenotype
• WikiPathways Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds: DVL2 → Complex of AXIN1-TNKS-GSK3B-APC-CSNK1A1-CTNNB1 (activation)
  
• WikiPathways Wnt Signaling in Kidney Disease: DVL2/DVL3/DVL1 → CTNNB1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: DVL2 — CTNNB1 (physical association, affinity chromatography technology) Song et al., J Biol Chem 2000*
• IRef Hprd Interaction: Complex of CSNK2A2-CSNK2A2-CTNNB1-CTNNB1-DVL2-DVL2-CTNNB1-CSNK2A2-DVL2 (in vivo) Song et al., J Biol Chem 2000*
• IRef Ophid Interaction: DVL2 — CTNNB1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

González-Sancho et al., Mol Cell Biol 2004 : Unlike the effects of Wnt1, phosphorylation of Dvl in response to Wnt5a is not concomitant with beta-catenin stabilization, indicating that Dvl phosphorylation is not sufficient to activate canonical Wnt/beta-catenin signaling
Yau et al., Oncogene 2005 (Carcinoma, Hepatocellular...) : Dishevelled ( Dvl ) , a key activator of the pathway, inhibits the adenomatous polyposis coli complex, and this leads to the accumulation of beta-catenin and promotes tumorigenesis
Bryja et al., Cell Signal 2007 : Thus, our results show that Wnt-3a rapidly induce a partial activation of beta-catenin in the absence of PS-Dvl at low doses, while at high doses induce a full activation of beta-catenin in a PS-Dvl dependent manner
Zhang et al., Cell Signal 2010 : Among these, Dishevelled ( Dvl ) is a critical regulator that releases beta-catenin from degradation and stabilizes TCF4/beta-catenin complex